DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atp5b and ATPsynbeta

DIOPT Version :9

Sequence 1:	NP_058054.2	Gene:	Atp5b / 11947	MGIID:	107801	Length:	529	Species:	Mus musculus
Sequence 2:	NP_001259081.1	Gene:	ATPsynbeta / 43829	FlyBaseID:	FBgn0010217	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	445/518 - (85%)
Similarity:	470/518 - (90%)	Gaps:	11/518 - (2%)

- Green bases have known domain annotations that are detailed below.

Mouse     9 ASASASGALRGLSPSAALPQAQLLLRAAPAGVHPARDYAAQASAAPKAGTATGRIVAVIGAVVDV 73
            |..:||.|.:.|.|  .|.|    |..||   ..||.:||:|:.|  |..|.|:|||||||||||
  Fly     3 ALRAASKADKNLLP--FLGQ----LSTAP---FSARSHAAKAAKA--AAAANGKIVAVIGAVVDV 56

Mouse    74 QFDEGLPPILNALEVQGRDSRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGP 138
            |||:.||||||||||..|..||||||||||||:|||||||||||||||||||||:|.||:||||.
  Fly    57 QFDDNLPPILNALEVDNRSPRLVLEVAQHLGENTVRTIAMDGTEGLVRGQKVLDTGYPIRIPVGA 121

Mouse   139 ETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFIEMSVEQEILVTGIKVVDLLAPYAKGGKIG 203
            ||||||:|||||||||||||.|.:.|.||||||||::||||||||||||||||||||||||||||
  Fly   122 ETLGRIINVIGEPIDERGPIDTDKTAAIHAEAPEFVQMSVEQEILVTGIKVVDLLAPYAKGGKIG 186

Mouse   204 LFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALV 268
            ||||||||||||||||||||||||||||||||||||||||||||:||||.|||:|||.|||||||
  Fly   187 LFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYNEMIEGGVISLKDKTSKVALV 251

Mouse   269 YGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQP 333
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   252 YGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQP 316

Mouse   334 TLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAV 398
            |||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   317 TLATDMGSMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAV 381

Mouse   399 DPLDSTSRIMDPNIVGNEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRF 463
            ||||||||||||||:|.|||:|||||||||||||||||||||||||||||||||||:||||||||
  Fly   382 DPLDSTSRIMDPNIIGQEHYNVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVARARKIQRF 446

Mouse   464 LSQPFQVAEVFTGHMGKLVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEE 526
            ||||||||||||||.||||||::|||||..||||:||||||.||||||||||.|.|||:||:|
  Fly   447 LSQPFQVAEVFTGHAGKLVPLEQTIKGFSAILAGDYDHLPEVAFYMVGPIEEVVEKADRLAKE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp5b	NP_058054.2	PRK09280	58..524	CDD:236447	424/465 (91%)
ATPsynbeta	NP_001259081.1	PRK09280	44..507	CDD:236447	423/462 (92%)
		ATP-synt_ab_N	46..112	CDD:280947	58/65 (89%)
		F1-ATPase_beta	114..393	CDD:238553	263/278 (95%)
		ATP-synt_ab_C	401..508	CDD:278722	94/106 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847042
Domainoid	1	1.000	421	1.000	Domainoid score	I637
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1273
Inparanoid	1	1.050	841	1.000	Inparanoid score	I442
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62497
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001822
OrthoInspector	1	1.000	-	-		oto91955
orthoMCL	1	0.900	-	-		OOG6_100608
Panther	1	1.100	-	-	LDO	PTHR15184
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R118
SonicParanoid	1	1.000	-	-		X1349
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790