DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atp5a1 and blw

DIOPT Version :9

Sequence 1:	NP_031531.1	Gene:	Atp5a1 / 11946	MGIID:	88115	Length:	553	Species:	Mus musculus
Sequence 2:	NP_726243.1	Gene:	blw / 37617	FlyBaseID:	FBgn0011211	Length:	552	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	448/553 - (81%)
Similarity:	499/553 - (90%)	Gaps:	5/553 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MLSVRVAAAVARALPRRAGLVS-KNALGSSFVGARNLHASNTRLQKTGTAEMSSILEERILGADT 64
            :.|.|:|::|||.||:.|..|: |.|..::.:.||.||.::|:    .:||:|:||||||||...
  Fly     3 IFSARLASSVARNLPKAANQVACKAAYPAASLAARKLHVASTQ----RSAEISNILEERILGVAP 63

Mouse    65 SVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFGNDKLIKEGD 129
            ..||||||||||||||||||:||.|:||:||||||||||||:||||||||||||||||||||:||
  Fly    64 KADLEETGRVLSIGDGIARVYGLNNIQADEMVEFSSGLKGMALNLEPDNVGVVVFGNDKLIKQGD 128

Mouse   130 VVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGIIPRISVREPMQTGIK 194
            :|||||||||||||:||||||||||||||||||.|.:|.|.|||:||||||||:|||||||||||
  Fly   129 IVKRTGAIVDVPVGDELLGRVVDALGNAIDGKGAINTKDRFRVGIKAPGIIPRVSVREPMQTGIK 193

Mouse   195 AVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGTDEKKKLYCIYVAIGQKRSTVAQL 259
            |||||||||||||||||||||||||::||||||||||||:..||.|||||||||||||||||||:
  Fly   194 AVDSLVPIGRGQRELIIGDRQTGKTALAIDTIINQKRFNEAQDESKKLYCIYVAIGQKRSTVAQI 258

Mouse   260 VKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYFRDNGKHALIIYDDLSKQAVAYRQM 324
            ||||||:.||.|:::||||||||||||||||||||:|||||||.|||||||||||||||||||||
  Fly   259 VKRLTDSGAMGYSVIVSATASDAAPLQYLAPYSGCAMGEYFRDKGKHALIIYDDLSKQAVAYRQM 323

Mouse   325 SLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDSFGGGSLTALPVIETQAGDVSAYIPTNVISIT 389
            |||||||||||||||||||||||||||||||:.:.||||||||||||||||||||||||||||||
  Fly   324 SLLLRRPPGREAYPGDVFYLHSRLLERAAKMSPAMGGGSLTALPVIETQAGDVSAYIPTNVISIT 388

Mouse   390 DGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLD 454
            ||||||||||||||||||||||||||||||||||:|||||||:||||||||||||||||||||||
  Fly   389 DGQIFLETELFYKGIRPAINVGLSVSRVGSAAQTKAMKQVAGSMKLELAQYREVAAFAQFGSDLD 453

Mouse   455 AATQQLLSRGVRLTELLKQGQYSPMAIEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVISQH 519
            |||||||:||||||||||||||.|||||:||||||.||||:|||::|:||||||..||.|:.:..
  Fly   454 AATQQLLNRGVRLTELLKQGQYVPMAIEDQVAVIYCGVRGHLDKMDPAKITKFEKEFLQHIKTSE 518

Mouse   520 QSLLGNIRSDGKISEQSDAKLKEIVTNFLAGFE 552
            |:||..|..||.|||.||||||:||..|::.|:
  Fly   519 QALLDTIAKDGAISEASDAKLKDIVAKFMSTFQ 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp5a1	NP_031531.1	PRK09281	49..553	CDD:236448	431/504 (86%)
		ATP-synt_ab_N	69..135	CDD:280947	58/65 (89%)
		F1_ATPase_alpha	137..418	CDD:238552	253/280 (90%)
		ATP-synt_ab_C	427..518	CDD:278722	76/90 (84%)
blw	NP_726243.1	PRK09281	46..552	CDD:236448	431/506 (85%)
		ATP-synt_ab_N	68..134	CDD:280947	58/65 (89%)
		F1_ATPase_alpha	136..417	CDD:238552	253/280 (90%)
		ATP-synt_ab_C	426..520	CDD:278722	76/93 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849654
Domainoid	1	1.000	408	1.000	Domainoid score	I699
eggNOG	1	0.900	-	-		E1_COG0056
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2985
Inparanoid	1	1.050	866	1.000	Inparanoid score	I417
Isobase	1	0.950	-	0	Normalized mean entropy	S65
OMA	1	1.010	-	-		QHG54695
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002237
OrthoInspector	1	1.000	-	-		oto94005
orthoMCL	1	0.900	-	-		OOG6_100771
Panther	1	1.100	-	-	LDO	PTHR48082
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R117
SonicParanoid	1	1.000	-	-		X1480
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740