DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp2a1 and SERCA

DIOPT Version :9

Sequence 1:	NP_031530.2	Gene:	Atp2a1 / 11937	MGIID:	105058	Length:	994	Species:	Mus musculus
Sequence 2:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster

Alignment Length:	994	Identity:	719/994 - (72%)
Similarity:	836/994 - (84%)	Gaps:	0/994 - (0%)

- Green bases have known domain annotations that are detailed below.

Mouse     1 MEAAHSKSTEECLSYFGVSETTGLTPDQVKRHLEKYGPNELPAEEGKSLWELVVEQFEDLLVRIL 65
            ||..|||:.|:.|::||.....|||.||:|.:.:||||||||.|||||:|:||:|||:||||:||
  Fly     1 MEDGHSKTVEQSLNFFGTDPERGLTLDQIKANQKKYGPNELPTEEGKSIWQLVLEQFDDLLVKIL 65

Mouse    66 LLAACISFVLAWFEEGEETVTAFVEPFVILLILIANAIVGVWQERNAENAIEALKEYEPEMGKVY 130
            ||||.||||||.|||.|||.||||||.||||||||||:||||||||||:|||||||||||||||.
  Fly    66 LLAAIISFVLALFEEHEETFTAFVEPLVILLILIANAVVGVWQERNAESAIEALKEYEPEMGKVV 130

Mouse   131 RADRKSVQRIKARDIVPGDIVEVAVGDKVPADIRILSIKSTTLRVDQSILTGESVSVIKHTDPVP 195
            |.|:..:|:::|::|||||:|||:||||:||||||..|.|||||:|||||||||||||||||.:|
  Fly   131 RQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAIP 195

Mouse   196 DPRAVNQDKKNMLFSGTNIAAGKAVGIVATTGVSTEIGKIRDQMAATEQDKTPLQQKLDEFGEQL 260
            |||||||||||:||||||:|||||.|:|..||:||.|||||.:|:.||:.|||||||||||||||
  Fly   196 DPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIGKIRTEMSETEEIKTPLQQKLDEFGEQL 260

Mouse   261 SKVISLICVAVWLINIGHFNDPVHGGSWFRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325
            |||||:||||||.|||||||||.|||||.:|||||||||||||||||||||||||||||||||||
  Fly   261 SKVISVICVAVWAINIGHFNDPAHGGSWIKGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRR 325

Mouse   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCKMFIIDKVDGDVCSLNEFSITGSTYA 390
            ||||||||||||||||||||||||||||||||||||||.:|||.|||:|:..|..||.:|||||.
  Fly   326 MAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEGNDSSFLEFEMTGSTYE 390

Mouse   391 PEGEVLKNDKPVRAGQYDGLVELATICALCNDSSLDFNETKGVYEKVGEATETALTTLVEKMNVF 455
            |.|||..|.:.::|..||.|.||:|||.:||||::|:||.|..:|||||||||||..|.||:|.|
  Fly   391 PIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGEATETALIVLAEKLNSF 455

Mouse   456 NTEVRSLSKVERANACNSVIRQLMKKEFTLEFSRDRKSMSVYCSPAKSSRAAVGNKMFVKGAPEG 520
            :.....|.:...|.||...|....||||||||||||||||.||:|.|:||...|.|:||||||||
  Fly   456 SVNKSGLDRRSAAIACRGEIETKWKKEFTLEFSRDRKSMSSYCTPLKASRLGTGPKLFVKGAPEG 520

Mouse   521 VIDRCNYVRVGTTRVPLTGPVKEKIMSVIKEWGTGRDTLRCLALATRDTPPKREEMVLDDSAKFM 585
            |::||.:.|||||:||||..:|.||:::..::|||||||||||||..|:|.|.:||.|.||.||.
  Fly   521 VLERCTHARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAVADSPMKPDEMDLGDSTKFY 585

Mouse   586 EYEMDLTFVGVVGMLDPPRKEVTGSIQLCRDAGIRVIMITGDNKGTAIAICRRIGIFSENEEVTD 650
            :||::|||||||||||||||||..||..||.||||||:||||||.||.|||||||:|:|:|:.|.
  Fly   586 QYEVNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVITGDNKATAEAICRRIGVFAEDEDTTG 650

Mouse   651 RAYTGREFDDLPLAEQREACRRACCFARVEPSHKSKIVEYLQSYDEITAMTGDGVNDAPALKKAE 715
            ::|:|||||||...||:.|..|:..|:||||.|||||||:|||.:||:|||||||||||||||||
  Fly   651 KSYSGREFDDLSPTEQKAAVARSRLFSRVEPQHKSKIVEFLQSMNEISAMTGDGVNDAPALKKAE 715

Mouse   716 IGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAA 780
            |||||||||||||:|:||||||||||:||:|||||||||||||||||||||||:||||.||||||
  Fly   716 IGIAMGSGTAVAKSAAEMVLADDNFSSIVSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAA 780

Mouse   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMDRPPRSPKEPLISGWLFFRYMAIGGYVG 845
            |||||||||||||||||||||||||||||||||||||::|||...|.||||||||||||||.|||
  Fly   781 LGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFYVG 845

Mouse   846 AATVGAAAWWFLYAEDGPHVSYHQLTHFMQCTEHNPEFDGLDCEVFEAPEPMTMALSVLVTIEMC 910
            |||||||||||:::::||.:||.||||.:.|.....||.|:||::|..|..|||||||||||||.
  Fly   846 AATVGAAAWWFVFSDEGPKLSYWQLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEML 910

Mouse   911 NALNSLSENQSLLRMPPWVNIWLLGSICLSMSLHFLILYVDPLPMIFKLRALDFTQWLMVLKISL 975
            ||:|||||||||:.||||.|:||:||:.||.:|||:|||||.|..:|::..|...:|:.|:|.|:
  Fly   911 NAMNSLSENQSLITMPPWCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSI 975

Mouse   976 PVIGLDELLKFIARNYLEG 994
            ||:.|||.|||:||...:|
  Fly   976 PVVLLDETLKFVARKIADG 994

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp2a1	NP_031530.2	P-type_ATPase_SERCA	5..989	CDD:319778	714/983 (73%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	788..808		19/19 (100%)
		Interaction with PLN. /evidence=ECO:0000250\|UniProtKB:P04191	932..943		6/10 (60%)
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	714/983 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	352	1.000	Domainoid score	I1004
eggNOG	1	0.900	-	-		E2759_KOG0202
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7635
Inparanoid	1	1.050	1448	1.000	Inparanoid score	I115
Isobase	1	0.950	-	0	Normalized mean entropy	S832
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D100699at2759
OrthoFinder	1	1.000	-	-		FOG0000231
OrthoInspector	1	1.000	-	-		otm43847
orthoMCL	1	0.900	-	-		OOG6_100158
Panther	1	1.100	-	-	LDO	PTHR42861
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3239
SonicParanoid	1	1.000	-	-		X745
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.820