DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atp1b1 and GABA-B-R1

DIOPT Version :9

Sequence 1:	NP_033851.1	Gene:	Atp1b1 / 11931	MGIID:	88108	Length:	304	Species:	Mus musculus
Sequence 2:	NP_001246033.1	Gene:	GABA-B-R1 / 34878	FlyBaseID:	FBgn0260446	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	294	Identity:	51/294 - (17%)
Similarity:	90/294 - (30%)	Gaps:	110/294 - (37%)

- Green bases have known domain annotations that are detailed below.

Mouse    16 IWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDR--VAPPGLT 78
            |||..:: .:..:......|:||.||.  ||..:.:..|....::..|.....|.|  :...|.|
  Fly   487 IWNKHRR-VIQSSHPVCNTIMLFGVII--CLISVILLGIDGRFVSPEEYPKICQARAWLLSTGFT 548

Mouse    79 --------QIPQIQKTEISFRPNDPKSYEAYVL------------------NIIRFLEKYKDSAQ 117
                    ::.::.:.....:.:..|..|.:.|                  .|...|::|.::..
  Fly   549 LAYGAMFSKVWRVHRFTTKAKTDPKKKVEPWKLYTMVSGLLSIDLVILLSWQIFDPLQRYLETFP 613

Mouse   118 KDDMIFEDCGNVPSEPKERGDINHERGERKVCRFKLDWLGNCSG--------------------- 161
            .:|.:     :...:.|.|.::.|...:|...     |||...|
  Fly   614 LEDPV-----STTDDIKIRPELEHCESQRNSM-----WLGLVYGFKGLILVFGLFLAYETRSIKV 668

Mouse   162 --LNDDSYG----YREGKPCIIIK--------------------------LNRVLGFKPK----- 189
              :||..|.    |.....|:|..                          |:.:|.|.||
  Fly   669 KQINDSRYVGMSIYNVVVLCLITAPVGMVIASQQDASFAFVALAVIFCCFLSMLLIFVPKVIEVI 733

Mouse   190 -PPKNESLETYPLMMKYNPNVLPVQCTGKRDEDK 222
             .||:::      ..||||:    ....|.||::
  Fly   734 RHPKDKA------ESKYNPD----SAISKEDEER 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp1b1	NP_033851.1	Na_K_ATPase_bet	1..304	CDD:273446	51/294 (17%)
Atp1b1	NP_033851.1	immunoglobulin-like. /evidence=ECO:0000250	191..304		9/32 (28%)
GABA-B-R1	NP_001246033.1	PBP1_GABAb_receptor	34..437	CDD:107361
		ANF_receptor	52..415	CDD:279440
		7tm_3	476..730	CDD:278433	42/255 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3927
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900