Protein Alignment CLIC2 and GstD7

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_525114.1
• Gene: GstD7 / 48340
• FlyBaseID: FBgn0010043
• Length: 224
• Species: Drosophila melanogaster
• Alignment Length: 223
• Identity: 50/223 - (22%)
• Similarity: 89/223 - (39%)
• Gaps: 49/223 - (21%)

Human    12 PEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNP----PF 72
            |.::|:        :....|..:.:.|:....|::.|...:: |.:.::||......||    |.
  Fly     2 PNLDLY--------NFPMAPASRAIQMVAKALGLELNSKLIN-TMEGDQLKPEFVRINPQHTIPT 57

Human    73 LVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKES---------FDVGC--NLFAKFSAYIKN 126
            ||.|..:..:...|..:|.:....|..| |.|...:.         ||:|.  :...|:...|..
  Fly    58 LVDNGFVIWESRAIAVYLVEKYGKPDSP-LYPNDPQKRALINQRLYFDMGTLYDALTKYFFLIFR 121

Human   127 TQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLN 191
            |.|..    ::..|.:......:||| .|:..|             |:.|.|||:||..:|..::
  Fly   122 TGKFG----DQEALDKVNSAFGFLNT-FLEGQD-------------FVAGSQLTVADIVILATVS 168

Human   192 IIKVAAKKYRDFDIPAEFSGVWRYLHNA 219
            .:     ::..||: ::|..|.|:|.||
  Fly   169 TV-----EWFSFDL-SKFPNVERWLKNA 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		17/87 (20%)
		N-terminal	1..94		17/85 (20%)
		O-ClC	12..245	CDD:129941	50/223 (22%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		1/2 (50%)
		Joint loop	95..106		4/10 (40%)
		C-terminal	107..247		29/124 (23%)
		Foot loop	151..171		4/19 (21%)
GstD7	NP_525114.1	GST_N_Delta_Epsilon	4..77	CDD:239343	16/81 (20%)
		GST_C_Delta_Epsilon	92..206	CDD:198287	29/123 (24%)