Protein Alignment CLIC2 and GstD4

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_524913.1
• Gene: GstD4 / 48337
• FlyBaseID: FBgn0010040
• Length: 215
• Species: Drosophila melanogaster
• Alignment Length: 198
• Identity: 46/198 - (23%)
• Similarity: 83/198 - (41%)
• Gaps: 40/198 - (20%)

Human    36 LFMILWLKGVKFNVTTVDMTR----KPEELKDLAPGTNPPFLVYN-----KELKTDFIKIEEFLE 91
            :.|:....|::.|...:.:|.    |||.|| |.|....|.||.|     :........:|::.:
  Fly    15 IIMVAKALGLELNKKQLRITEGEHLKPEFLK-LNPQHTIPTLVDNGFAIWESRAIAVYLVEKYGK 78

Human    92 QTLAPPRYPHLSPKYKES--FDVGC--NLFAK-FSAYIKNTQKEANKNFEKSLLKEFKRLDDYLN 151
            .....|..|.......:.  ||:|.  :.|.| :..:|:..|....:|::| :...|:.||.:|
  Fly    79 DDSLFPNDPQKRALINQRLYFDMGTLHDSFMKYYYPFIRTGQLGNAENYKK-VEAAFEFLDIFL- 141

Human   152 TPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYL 216
                             ..:.::.|.|||:||.::|..::..:|.     :||| :::..|.|:.
  Fly   142 -----------------EGQDYVAGSQLTVADIAILSSVSTFEVV-----EFDI-SKYPNVARWY 183

Human   217 HNA 219
            .||
  Fly   184 ANA 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		16/68 (24%)
		N-terminal	1..94		16/66 (24%)
		O-ClC	12..245	CDD:129941	46/198 (23%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33
		Joint loop	95..106		2/10 (20%)
		C-terminal	107..247		28/118 (24%)
		Foot loop	151..171		0/19 (0%)
GstD4	NP_524913.1	GST_N_Delta_Epsilon	1..74	CDD:239343	15/59 (25%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	28/124 (23%)