Protein Alignment CLIC2 and GstD3

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_788656.1
• Gene: GstD3 / 48336
• FlyBaseID: FBgn0010039
• Length: 199
• Species: Drosophila melanogaster
• Alignment Length: 207
• Identity: 45/207 - (21%)
• Similarity: 77/207 - (37%)
• Gaps: 82/207 - (39%)

Human    44 GVKFNVTTVDMTRKPEELKDLAPGTNPPF-------------------------LVY--NKELKT 81
            |::||...:: |.|.|::       ||.|                         |||  .|..|.
  Fly     7 GLEFNKKIIN-TLKGEQM-------NPDFIKINPQHSIPTLVDNGFTIWESRAILVYLVEKYGKD 63

Human    82 DFIKIEEFLEQTLAPPR--------YPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKS 138
            |.:..::..:|.:...|        ||.|:..|.::|..|     :|.:  :...|:..:.|
  Fly    64 DALYPKDIQKQAVINQRLYFDMALMYPTLANYYYKAFTTG-----QFGS--EEDYKKVQETF--- 118

Human   139 LLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDF 203
                     |:||| .|:..|             ::.|||.|:||.::|..::...|..     |
  Fly   119 ---------DFLNT-FLEGQD-------------YVAGDQYTVADIAILANVSNFDVVG-----F 155

Human   204 DIPAEFSGVWRY 215
            || :::..|.|:
  Fly   156 DI-SKYPNVARW 166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		16/78 (21%)
		N-terminal	1..94		16/76 (21%)
		O-ClC	12..245	CDD:129941	45/207 (22%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33
		Joint loop	95..106		4/18 (22%)
		C-terminal	107..247		24/109 (22%)
		Foot loop	151..171		4/19 (21%)
GstD3	NP_788656.1	GST_N_Delta_Epsilon	<1..58	CDD:239343	12/58 (21%)
		GST_C_Delta_Epsilon	72..188	CDD:198287	30/134 (22%)