Protein Alignment CLIC2 and GstD2

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_524912.1
• Gene: GstD2 / 48335
• FlyBaseID: FBgn0010038
• Length: 215
• Species: Drosophila melanogaster
• Alignment Length: 221
• Identity: 52/221 - (23%)
• Similarity: 91/221 - (41%)
• Gaps: 50/221 - (22%)

Human    14 IELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNP----PFLV 74
            ::.:...|..|        |:.:.|:....|::.|...:: |.:.|:||......||    |.||
  Fly     1 MDFYYMPGGGG--------CRTVIMVAKALGLELNKKLLN-TMEGEQLKPEFVKLNPQHTIPTLV 56

Human    75 YNKELKTDFIKIEEFLEQTLAPPRY--PHLSPKYKE------SFDVGCNLFAKFSAY---IKNTQ 128
            .|.....:...|..:|.:......|  |: .||.:.      .||:| .|:..|:.|   :..|.
  Fly    57 DNGFSIWESRAIAVYLVEKYGKDDYLLPN-DPKKRAVINQRLYFDMG-TLYESFAKYYYPLFRTG 119

Human   129 KEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNII 193
            |..:....|.:...|..||.:|           ..:|       ::.|||||:||.::|..::..
  Fly   120 KPGSDEDLKRIETAFGFLDTFL-----------EGQE-------YVAGDQLTVADIAILSTVSTF 166

Human   194 KVAAKKYRDFDIPAEFSGVWRYLHNA 219
            :|:     :||. :::|.|.|:..||
  Fly   167 EVS-----EFDF-SKYSNVSRWYDNA 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		18/85 (21%)
		N-terminal	1..94		18/83 (22%)
		O-ClC	12..245	CDD:129941	52/221 (24%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		0/2 (0%)
		Joint loop	95..106		3/12 (25%)
		C-terminal	107..247		30/122 (25%)
		Foot loop	151..171		1/19 (5%)
GstD2	NP_524912.1	GST_N_Delta_Epsilon	1..74	CDD:239343	18/81 (22%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	31/124 (25%)