Protein Alignment CLIC2 and GstD1

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_524326.1
• Gene: GstD1 / 41503
• FlyBaseID: FBgn0001149
• Length: 209
• Species: Drosophila melanogaster
• Alignment Length: 205
• Identity: 51/205 - (24%)
• Similarity: 87/205 - (42%)
• Gaps: 39/205 - (19%)

Human    28 GNCPFCQRLFMILWLKGVKFNVTTVDMTR----KPEELKDLAPGTNPPFLVYNKELKTDFIKIEE 88
            |:.| |:.:.|.....||:.|...:::..    |||.|| :.|....|.||.|.....:...|:.
  Fly     9 GSSP-CRSVIMTAKAVGVELNKKLLNLQAGEHLKPEFLK-INPQHTIPTLVDNGFALWESRAIQV 71

Human    89 FLEQTLAPPRYPHLSPKYKES---------FDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFK 144
            :|.:...  :...|.||..:.         ||:| .|:..|:.|. ..|..|....:....|:.:
  Fly    72 YLVEKYG--KTDSLYPKCPKKRAVINQRLYFDMG-TLYQSFANYY-YPQVFAKAPADPEAFKKIE 132

Human   145 RLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEF 209
            ...::||| .|:..|             :..||.||:||.:|:..::..:||     .|:| :::
  Fly   133 AAFEFLNT-FLEGQD-------------YAAGDSLTVADIALVATVSTFEVA-----KFEI-SKY 177

Human   210 SGVWRYLHNA 219
            :.|.|:..||
  Fly   178 ANVNRWYENA 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		19/71 (27%)
		N-terminal	1..94		19/69 (28%)
		O-ClC	12..245	CDD:129941	51/205 (25%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		1/2 (50%)
		Joint loop	95..106		2/10 (20%)
		C-terminal	107..247		29/122 (24%)
		Foot loop	151..171		4/19 (21%)
GstD1	NP_524326.1	GST_N_Delta_Epsilon	2..75	CDD:239343	19/67 (28%)
		GST_C_Delta_Epsilon	89..205	CDD:198287	29/121 (24%)