Protein Alignment CLIC2 and GstD9

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_650181.1
• Gene: GstD9 / 41502
• FlyBaseID: FBgn0038020
• Length: 218
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 46/214 - (21%)
• Similarity: 83/214 - (38%)
• Gaps: 64/214 - (29%)

Human    33 CQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIE-EFLEQTLAP 96
            |:.:.|.....|::.|...||:..                   .:.||.:|:||. :....||..
  Fly    13 CRSILMTARALGLELNKKQVDLDA-------------------GEHLKPEFVKINPQHTIPTLVD 58

Human    97 PRYP---------HLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKN----FEKSLLKEFKRLDD 148
            ..:.         :|:.||.:.          .|.|.|:.|:.|..|    |:.|.|  ::....
  Fly    59 DGFAIWESRAILIYLAEKYDKD----------GSLYPKDPQQRAVINQRLFFDLSTL--YQSYVY 111

Human   149 YLNTPLLDEI----DPDSAEEPPVSRRLF---LDGDQ------LTLADCSLLPKLNIIKVAAKKY 200
            |....|.:::    |||:.::...:..:|   |.|.|      |||||.:||..::..:::
  Fly   112 YYYPQLFEDVKKPADPDNLKKIDDAFAMFNTLLKGQQYAALNKLTLADFALLATVSTFEIS---- 172

Human   201 RDFDIPAEFSGVWRYLHNA 219
             ::|. .::..|.|:..||
  Fly   173 -EYDF-GKYPEVVRWYDNA 189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		13/63 (21%)
		N-terminal	1..94		11/61 (18%)
		O-ClC	12..245	CDD:129941	46/214 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		46/214 (21%)
		Joint loop	95..106		1/19 (5%)
		C-terminal	107..247		30/130 (23%)
		Foot loop	151..171		4/23 (17%)
GstD9	NP_650181.1	GstA	1..187	CDD:440390	44/210 (21%)