Protein Alignment CLIC2 and GstO1

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_648237.1
• Gene: GstO1 / 38975
• FlyBaseID: FBgn0035907
• Length: 254
• Species: Drosophila melanogaster
• Alignment Length: 205
• Identity: 45/205 - (21%)
• Similarity: 80/205 - (39%)
• Gaps: 42/205 - (20%)

Human    30 CPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTL 94
            ||:..|:.::|..|.:.::...:::..|||....::..|..|.|...|| :.:.:.||..:....
  Fly    30 CPYAHRVHLVLDAKKIPYHAIYINLRDKPEWFSLVSSSTKVPALELVKE-QGNPVLIESLIICDY 93

Human    95 APPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDE-- 157
            ...:||.:                  ..|.|:..|:|.   ||.|::.|.:..:.....||.:
  Fly    94 LDEKYPEV------------------PLYPKDLLKKAQ---EKILIERFGQFINAFYYLLLHDNP 137

Human   158 ---IDPDS-----AEEPPVSRRL--FLDGDQLTLADCSLLPKLNIIKVAAKKY---RDFDI-PAE 208
               :|.|.     ..|..:.||.  |..||...:.|..:.|...  :..:.||   :.|:: |..
  Fly   138 EQLVDTDHYAGLVVYEEELKRRCTKFFGGDSPGMLDYMMWPWCE--RFDSLKYTFEQKFELSPER 200

Human   209 FSGV--WRYL 216
            |..:  ||.|
  Fly   201 FPTLIKWRDL 210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		15/65 (23%)
		N-terminal	1..94		15/63 (24%)
		O-ClC	12..245	CDD:129941	45/205 (22%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		2/2 (100%)
		Joint loop	95..106		2/10 (20%)
		C-terminal	107..247		28/128 (22%)
		Foot loop	151..171		5/29 (17%)
GstO1	NP_648237.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	3..95	CDD:469754	15/65 (23%)
		GST_C_Omega	109..234	CDD:198293	26/107 (24%)