DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLIC2 and GstO2

DIOPT Version :10

Sequence 1:NP_001280.3 Gene:CLIC2 / 1193 HGNCID:2063 Length:247 Species:Homo sapiens
Sequence 2:NP_729388.1 Gene:GstO2 / 38974 FlyBaseID:FBgn0035906 Length:251 Species:Drosophila melanogaster


Alignment Length:125 Identity:35/125 - (28%)
Similarity:54/125 - (43%) Gaps:11/125 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    26 SIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFL----VYNKELKTDFIKI 86
            |:..|||..|:.::|..|.::.:...||:..|||..||.:|....|.|    |.::....:.:.|
  Fly    27 SMAFCPFSHRVRLMLAAKHIEHHKIYVDLIEKPEWYKDFSPLGKVPALQLTGVKDQPTLVESLII 91

Human    87 EEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYI-------KNTQKEANKNFEKSL 139
            .|:|:|.....|.....|..|....:....||...:.|       .|..|:|..|||.:|
  Fly    92 AEYLDQQYPQTRLFPTDPLQKALDKILIERFAPVVSAIYPVLTCNPNAPKDAIPNFENAL 151

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIC2NP_001280.3 Required for insertion into the membrane. /evidence=ECO:0000250 1..96 22/73 (30%)
N-terminal 1..94 22/71 (31%)
O-ClC 12..245 CDD:129941 35/125 (28%)
G-site. /evidence=ECO:0000305|PubMed:25581026 30..33 2/2 (100%)
Joint loop 95..106 2/10 (20%)
C-terminal 107..247 11/40 (28%)
Foot loop 151..171
GstO2NP_729388.1 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold 5..96 CDD:469754 20/68 (29%)
GST_C_Omega 110..235 CDD:198293 11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.