Protein Alignment CLIC2 and GstO3

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_648234.1
• Gene: GstO3 / 38972
• FlyBaseID: FBgn0035904
• Length: 241
• Species: Drosophila melanogaster
• Alignment Length: 229
• Identity: 53/229 - (23%)
• Similarity: 91/229 - (39%)
• Gaps: 58/229 - (25%)

Human    30 CPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTL 94
            ||:.||..::|..|.|.::...:::|.|||.|.:::|....|.|....|      |.|..|.::|
  Fly    30 CPYAQRAHLVLNAKNVPYHSVYINLTEKPEWLVEVSPLLKVPALQLVAE------KGEPSLIESL 88

Human    95 APPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKR-------------- 145
            ....|  |..||.|:           ....|:..|.|.   :|.||:.|..
  Fly    89 IIAEY--LDDKYPEN-----------PLLPKDPLKRAQ---DKILLERFSSITSAFINILVQGTG 137

Human   146 LDDYLNTPLLDEIDPDSAEEPPVSRRL-FLDGDQLTLADCSLLP---KLNIIKVAAKKYRDFDIP 206
            |:||. |.|      |..||....|.. :..|::....|..:.|   :|::|::..:|..:|: .
  Fly   138 LEDYW-TAL------DIFEEELTKRGTPYFGGNKPGFVDYMIWPWFERLSVIELKLQKEYNFN-E 194

Human   207 AEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYA 240
            :.|..:.:::....|          |..:::.||
  Fly   195 SRFPKITKWIALLKA----------DSVVQSFYA 218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		20/65 (31%)
		N-terminal	1..94		19/63 (30%)
		O-ClC	12..245	CDD:129941	53/229 (23%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		2/2 (100%)
		Joint loop	95..106		2/10 (20%)
		C-terminal	107..247		29/152 (19%)
		Foot loop	151..171		5/19 (26%)
GstO3	NP_648234.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	3..95	CDD:469754	21/72 (29%)
		GST_C_Omega	109..230	CDD:198293	27/131 (21%)