Protein Alignment CLIC2 and GstE11

DIOPT Version :10

• Sequence 1: NP_001280.3
• Gene: CLIC2 / 1193
• HGNCID: 2063
• Length: 247
• Species: Homo sapiens
• Sequence 2: NP_611339.1
• Gene: GstE11 / 37128
• FlyBaseID: FBgn0034354
• Length: 225
• Species: Drosophila melanogaster
• Alignment Length: 183
• Identity: 39/183 - (21%)
• Similarity: 66/183 - (36%)
• Gaps: 35/183 - (19%)

Human    31 PFCQRLFMILWLKGVKFNVTTVDM---TRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQ 92
            |.|:.:.:.....|::.::..|::   ..|..|...|......|.|..|..:.:|...|..:|..
  Fly    14 PPCRAVLLTAAALGLELDLRLVNVKAGEHKSAEFLKLNAQHTIPVLDDNGTIVSDSHIICSYLAD 78

Human    93 TLAPPRYPHLSPKYKES---------FDVGCNLFAKFSAYIKNT----QKEANKNFEKSLLKEFK 144
            ..||.....|.||..|.         :|.| :||.:....::..    ..|...:....|.|.:.
  Fly    79 KYAPEGDDSLYPKDPEKRRLVDARLYYDCG-HLFPRIRFIVEPVIYFGAGEVPSDRVAYLQKAYD 142

Human   145 RLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAA 197
            .|:..|            ||..      :|.||:||:||.|.:..::..:..|
  Fly   143 GLEHCL------------AEGD------YLVGDKLTIADLSCIASVSTAEAFA 177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC2	NP_001280.3	Required for insertion into the membrane. /evidence=ECO:0000250	1..96		13/67 (19%)
		N-terminal	1..94		13/65 (20%)
		O-ClC	12..245	CDD:129941	39/183 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	30..33		1/1 (100%)
		Joint loop	95..106		4/10 (40%)
		C-terminal	107..247		21/104 (20%)
		Foot loop	151..171		2/19 (11%)
GstE11	NP_611339.1	GST_N_Delta_Epsilon	5..78	CDD:239343	13/63 (21%)
		GST_C_Delta_Epsilon	94..211	CDD:198287	21/103 (20%)