DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLIC2 and GstE8

DIOPT Version :10

Sequence 1:NP_001280.3 Gene:CLIC2 / 1193 HGNCID:2063 Length:247 Species:Homo sapiens
Sequence 2:NP_611330.2 Gene:GstE8 / 37113 FlyBaseID:FBgn0063492 Length:222 Species:Drosophila melanogaster


Alignment Length:162 Identity:34/162 - (20%)
Similarity:60/162 - (37%) Gaps:66/162 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    82 DFIKIEEFLEQTLAP------PRYPHLSPKYK-------ESFDVGCNLFAKF----SAYIKNTQK 129
            :::||....::||:|      |:  |..|..:       :|..:...|.:|:    :.|.|:..:
  Fly    30 EYVKINTLAKETLSPEFLRKNPQ--HTVPTLEDDGHFIWDSHAISAYLVSKYGQSDTLYPKDLLQ 92

Human   130 EA----NKNFEKSLL---------------------KEFKRLD------DYLNTPLLDEIDPDSA 163
            .|    ..:||..::                     ||  |.|      |::.|.|         
  Fly    93 RAVVDQRLHFESGVVFVNGLRGITKPLFATGQTTIPKE--RYDAVIEIYDFVETFL--------- 146

Human   164 EEPPVSRRLFLDGDQLTLADCSLLPKLNIIKV 195
                 :...|:.|||||:||.||:..:..:.|
  Fly   147 -----TGHDFIAGDQLTIADFSLITSITALAV 173

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIC2NP_001280.3 Required for insertion into the membrane. /evidence=ECO:0000250 1..96 4/13 (31%)
N-terminal 1..94 2/11 (18%)
O-ClC 12..245 CDD:129941 34/162 (21%)
G-site. /evidence=ECO:0000305|PubMed:25581026 30..33
Joint loop 95..106 4/16 (25%)
C-terminal 107..247 26/131 (20%)
Foot loop 151..171 2/19 (11%)
GstE8NP_611330.2 GstA 4..209 CDD:440390 34/162 (21%)
Blue background indicates that the domain is not in the aligned region.

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