DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLIC2 and GstE3

DIOPT Version :10

Sequence 1:NP_001280.3 Gene:CLIC2 / 1193 HGNCID:2063 Length:247 Species:Homo sapiens
Sequence 2:NP_611325.2 Gene:GstE3 / 37108 FlyBaseID:FBgn0063497 Length:220 Species:Drosophila melanogaster


Alignment Length:173 Identity:40/173 - (23%)
Similarity:69/173 - (39%) Gaps:44/173 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    69 NPP---FLVYNKELKTDF-IKIEEFLEQTLAPPRYPHLSPKY------------KESFDVGCNLF 117
            :||   .|:..:.|..|| .||...:|:....|.:..::|.:            .:|..:...|.
  Fly    12 SPPVRSVLLTLRALNLDFDYKIVNLMEKEHLKPEFLKINPLHTVPALDDNGFYLADSHAINSYLV 76

Human   118 AKF----SAYIKNTQKEA----NKNFEKSLLKEFKRLDDYLNTPL-------LDEIDPDSAEEPP 167
            :|:    |.|.|:.:|.|    ..:::.|::....|.   :..||       :.:...|:.|...
  Fly    77 SKYGRNDSLYPKDLKKRAIVDQRLHYDSSVVTSTGRA---ITFPLFWENKTEIPQARIDALEGVY 138

Human   168 VSRRLFLD------GDQLTLADCSLLPKLN----IIKVAAKKY 200
            .|..|||:      ||.||:||..::..|.    .:.|.|.||
  Fly   139 KSLNLFLENGNYLAGDNLTIADFHVIAGLTGFFVFLPVDATKY 181

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIC2NP_001280.3 Required for insertion into the membrane. /evidence=ECO:0000250 1..96 9/30 (30%)
N-terminal 1..94 9/28 (32%)
O-ClC 12..245 CDD:129941 40/173 (23%)
G-site. /evidence=ECO:0000305|PubMed:25581026 30..33
Joint loop 95..106 2/10 (20%)
C-terminal 107..247 29/119 (24%)
Foot loop 151..171 5/26 (19%)
GstE3NP_611325.2 GstA 4..200 CDD:440390 40/173 (23%)
Blue background indicates that the domain is not in the aligned region.

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