DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLIC2 and GstE2

DIOPT Version :10

Sequence 1:NP_001280.3 Gene:CLIC2 / 1193 HGNCID:2063 Length:247 Species:Homo sapiens
Sequence 2:NP_611324.1 Gene:GstE2 / 37107 FlyBaseID:FBgn0063498 Length:221 Species:Drosophila melanogaster


Alignment Length:144 Identity:36/144 - (25%)
Similarity:52/144 - (36%) Gaps:44/144 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    94 LAPP--------RYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRL---- 146
            ::||        |..:|..:|||     .:|.|  ..:.|:...:.|......||::...|    
  Fly    12 ISPPVRACKLTLRALNLDYEYKE-----MDLLA--GDHFKDAFLKKNPQHTVPLLEDNGALIWDS 69

Human   147 --------DDYLNTPLLDEIDP-DSAEEPPVSRRLFLDGDQL-----------TLADCSLLPKLN 191
                    |.|.|:   ||:.| |......|.:|||.|...|           .|...||:||..
  Fly    70 HAIVCYLVDKYANS---DELYPRDLVLRAQVDQRLFFDASILFMSLRNVSIPYFLRQVSLVPKEK 131

Human   192 I--IKVAAKKYRDF 203
            :  ||.|.....:|
  Fly   132 VDNIKDAYGHLENF 145

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIC2NP_001280.3 Required for insertion into the membrane. /evidence=ECO:0000250 1..96 0/1 (0%)
N-terminal 1..94 36/144 (25%)
O-ClC 12..245 CDD:129941 36/144 (25%)
G-site. /evidence=ECO:0000305|PubMed:25581026 30..33
Joint loop 95..106 4/18 (22%)
C-terminal 107..247 31/123 (25%)
Foot loop 151..171 6/20 (30%)
GstE2NP_611324.1 GstA 5..200 CDD:440390 36/144 (25%)
Blue background indicates that the domain is not in the aligned region.

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