DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLIC2 and GstE1

DIOPT Version :10

Sequence 1:NP_001280.3 Gene:CLIC2 / 1193 HGNCID:2063 Length:247 Species:Homo sapiens
Sequence 2:NP_611323.1 Gene:GstE1 / 37106 FlyBaseID:FBgn0034335 Length:224 Species:Drosophila melanogaster


Alignment Length:216 Identity:44/216 - (20%)
Similarity:63/216 - (29%) Gaps:98/216 - (45%)


- Green bases have known domain annotations that are detailed below.


Human   102 LSPKYKESFDVGCNLFAKFSAYIKNTQ---KEANKNFEKSLLKEFKRLDDYLNTPLL-------- 155
            |||         |....|.:..:.|..   ||.|....:.|.:|:.:.:.....|:|        
  Fly    13 LSP---------CVRTVKLTLKVLNLDYEYKEVNLQAGEHLSEEYVKKNPQHTVPMLDDNGTFIW 68

Human   156 ----------------DEIDP-DSAEEPPVSRRLFLD---------------------------- 175
                            ||:.| |.|:...|::|||.|                            
  Fly    69 DSHAIAAYLVDKYAKSDELYPKDLAKRAIVNQRLFFDASVIYASIANVSRPFWINGVTEVPQEKL 133

Human   176 ---------------------GDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNA 219
                                 ||.|||||.|..|.::.:..|.    |.| ||.:..|..:|   
  Fly   134 DAVHQGLKLLETFLGNSPYLAGDSLTLADLSTGPTVSAVPAAV----DID-PATYPKVTAWL--- 190

Human   220 YAREEFTHTCPEDKEIENTYA 240
                :..:..|..|||....|
  Fly   191 ----DRLNKLPYYKEINEAPA 207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIC2NP_001280.3 Required for insertion into the membrane. /evidence=ECO:0000250 1..96
N-terminal 1..94
O-ClC 12..245 CDD:129941 44/216 (20%)
G-site. /evidence=ECO:0000305|PubMed:25581026 30..33
Joint loop 95..106 3/3 (100%)
C-terminal 107..247 41/211 (19%)
Foot loop 151..171 8/44 (18%)
GstE1NP_611323.1 GstA 6..201 CDD:440390 40/208 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.