DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atoh1 and tx

DIOPT Version :9

Sequence 1:	NP_031526.1	Gene:	Atoh1 / 11921	MGIID:	104654	Length:	351	Species:	Mus musculus
Sequence 2:	NP_001287543.1	Gene:	tx / 43190	FlyBaseID:	FBgn0263118	Length:	384	Species:	Drosophila melanogaster

Alignment Length:	296	Identity:	72/296 - (24%)
Similarity:	107/296 - (36%)	Gaps:	84/296 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    55 DSTDPRAWLTPTLQGLCTARAAQYLLHS--PELGASEAAAPRDEADSQGELVRRSGCGGLSKSPG 117
            ||.|.|...|      .:||..:|.|..  .:.|::|.....:.||.|.||...:.....|:...
  Fly    22 DSKDSRKRKT------ASARGEKYSLRQKRQKRGSNEDGESANLADFQLELDPIAEPASKSRKNA 80

Mouse   118 PVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNV 182
            |.|                   |:.:||.      :.|.||..||||||.||..:|.||:.||:.
  Fly    81 PTK-------------------SKTKAPP------LSKYRRKTANARERTRMREINTAFETLRHC 120

Mouse   183 IP-------SFNNDKKLSKYETLQMAQIYINALSELLQTPN-----VGEQPPPPTASCKNDHHHL 235
            :|       :.|.::||:|..||::|..||..|::.::.|:     :||        |..:..:.
  Fly   121 VPEAIKGEDAANTNEKLTKITTLRLAMKYITMLTDSIRDPSYESEFIGE--------CLEESANR 177

Mouse   236 RTASSYEGGAGASAVAGAQPAPGGGPRPTPPGPCRTRFSG----------------------PAS 278
            ......|....|....         |.|....|.:|:.||                      |.|
  Fly   178 EARVDLEANEEAEVEL---------PVPVAKKPAKTKGSGKKSSAASKRQSQKQAKIVPQIPPIS 233

Mouse   279 SGGYSVQLDALHFPAFEDRALTAMMAQKDLSPSLPG 314
            ||.......::..||....|..:..:....|.|.||
  Fly   234 SGESCYATSSIGSPASSAYASLSSSSNSHSSSSSPG 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atoh1	NP_031526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..116		7/26 (27%)
		HLH	155..213	CDD:238036	27/64 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..278		8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..351		4/7 (57%)
tx	NP_001287543.1	HLH	95..154	CDD:278439	25/58 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810