DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atoh1 and ato

DIOPT Version :9

Sequence 1:	NP_031526.1	Gene:	Atoh1 / 11921	MGIID:	104654	Length:	351	Species:	Mus musculus
Sequence 2:	NP_731223.1	Gene:	ato / 40975	FlyBaseID:	FBgn0010433	Length:	312	Species:	Drosophila melanogaster

Alignment Length:	182	Identity:	62/182 - (34%)
Similarity:	85/182 - (46%)	Gaps:	20/182 - (10%)

- Green bases have known domain annotations that are detailed below.

Mouse    33 PQPPATLQARDLPVYPAELSLLDSTDPRAWLTPTLQGLCTARAAQYLLHSPELGASEAAAPRDEA 97
            |:|..:...::.|          ||  .|..|||.....:|....|...........:|...|..
  Fly   150 PKPKRSYTKKNQP----------ST--TATSTPTAAAESSASVNLYTEEFQNFDFDNSALFDDSV 202

Mouse    98 DSQGELVRRSGCGGLSKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNG-VQKQRRLAA 161
            :...:|:..||......:.|..       .|..|...|.......:....||:.. |:::|||||
  Fly   203 EDDEDLMLFSGGEDFDGNDGSF-------DLADGENQDAAAGGSGKKRRGKQITPVVKRKRRLAA 260

Mouse   162 NARERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQ 213
            ||||||||..||.|||:||..:|...||::|||:|||||||.||:||.:||:
  Fly   261 NARERRRMQNLNQAFDRLRQYLPCLGNDRQLSKHETLQMAQTYISALGDLLR 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atoh1	NP_031526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..39		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..116		5/26 (19%)
		HLH	155..213	CDD:238036	38/57 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..278
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..351
ato	NP_731223.1	HLH	253..312	CDD:238036	38/58 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835487
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.870