DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atoh1 and cato

DIOPT Version :9

Sequence 1:	NP_031526.1	Gene:	Atoh1 / 11921	MGIID:	104654	Length:	351	Species:	Mus musculus
Sequence 2:	NP_477344.1	Gene:	cato / 36813	FlyBaseID:	FBgn0024249	Length:	189	Species:	Drosophila melanogaster

Alignment Length:	167	Identity:	65/167 - (38%)
Similarity:	82/167 - (49%)	Gaps:	52/167 - (31%)

- Green bases have known domain annotations that are detailed below.

Mouse    61 AWLTPTLQGLCTARAAQYLLHSPELGASEAAAPRDEAD---SQGELVRRS----GCGGLSKSPGP 118
            |:|:|..|.|..|...|     .|||      |..||.   :|.:..|||    |..|...||
  Fly    40 AFLSPEWQFLDAAGGTQ-----TELG------PIMEAQGQHTQPQTKRRSNSFTGSDGRKSSP-- 91

Mouse   119 VKVREQLCKLKGGVVVDELGCSRQRAPSSKQVN---GVQKQRRLAANARERRRMHGLNHAFDQLR 180
                                         :|.|   .|||:||.|||||||:||:|||.||::||
  Fly    92 -----------------------------EQTNLSPTVQKRRRQAANARERKRMNGLNAAFERLR 127

Mouse   181 NVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPNV 217
            .|:|:.:.|:||||:|||||||.||.||.:||...:|
  Fly   128 EVVPAPSIDQKLSKFETLQMAQSYILALCDLLNNGDV 164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atoh1	NP_031526.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..39
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..116		9/33 (27%)
		HLH	155..213	CDD:238036	38/57 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	244..278
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..351
cato	NP_477344.1	HLH	104..155	CDD:278439	34/50 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	1	1.000	-	-		X4691
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.900