Protein Alignment CLIC1 and GstD2

DIOPT Version :10

• Sequence 1: NP_001279.2
• Gene: CLIC1 / 1192
• HGNCID: 2062
• Length: 241
• Species: Homo sapiens
• Sequence 2: NP_524912.1
• Gene: GstD2 / 48335
• FlyBaseID: FBgn0010038
• Length: 215
• Species: Drosophila melanogaster
• Alignment Length: 209
• Identity: 42/209 - (20%)
• Similarity: 78/209 - (37%)
• Gaps: 49/209 - (23%)

Human    22 GNCPFSQRLFMVLWLKGVTFN---VTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEF 83
            |.|   :.:.||....|:..|   :.|::.::......||.|...:|.|:.......::..|..:
  Fly    10 GGC---RTVIMVAKALGLELNKKLLNTMEGEQLKPEFVKLNPQHTIPTLVDNGFSIWESRAIAVY 71

Human    84 L------EAVLCPPRYPKLAALNPESNTAGLDIFAKFSAY----IKNSNPALNDNLEKGLLKALK 138
            |      :..|.|....|.|.:|.........::..|:.|    .:...|..:::| |.:..|..
  Fly    72 LVEKYGKDDYLLPNDPKKRAVINQRLYFDMGTLYESFAKYYYPLFRTGKPGSDEDL-KRIETAFG 135

Human   139 VLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPE-- 201
            .||.:|               ||   ::::.|::||:||..:|..:..          |.:.|
  Fly   136 FLDTFL---------------EG---QEYVAGDQLTVADIAILSTVST----------FEVSEFD 172

Human   202 --AFRGVHRYLSNA 213
              .:..|.|:..||
  Fly   173 FSKYSNVSRWYDNA 186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC1	NP_001279.2	Required for insertion into the membrane	2..90		15/76 (20%)
		O-ClC	6..241	CDD:129941	42/209 (20%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	24..27		1/2 (50%)
GstD2	NP_524912.1	GST_N_Delta_Epsilon	1..74	CDD:239343	14/66 (21%)
		GST_C_Delta_Epsilon	88..204	CDD:198287	26/128 (20%)