Protein Alignment CLIC1 and GstO1

DIOPT Version :10

• Sequence 1: NP_001279.2
• Gene: CLIC1 / 1192
• HGNCID: 2062
• Length: 241
• Species: Homo sapiens
• Sequence 2: NP_648237.1
• Gene: GstO1 / 38975
• FlyBaseID: FBgn0035907
• Length: 254
• Species: Drosophila melanogaster
• Alignment Length: 231
• Identity: 40/231 - (17%)
• Similarity: 74/231 - (32%)
• Gaps: 89/231 - (38%)

Human    24 CPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFL----LYGTEVHTDTNKIEEFL 84
            ||::.|:.:||..|.:.::...::.:.:.|....:....::|.|    ..|..|..::..|.::|
  Fly    30 CPYAHRVHLVLDAKKIPYHAIYINLRDKPEWFSLVSSSTKVPALELVKEQGNPVLIESLIICDYL 94

Human    85 EAVLCP--PRYPK-------------------------LAALNPE-----SNTAGLDIF-----A 112
            :... |  |.|||                         |...|||     .:.|||.::     .
  Fly    95 DEKY-PEVPLYPKDLLKKAQEKILIERFGQFINAFYYLLLHDNPEQLVDTDHYAGLVVYEEELKR 158

Human   113 KFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVD----------ETSAED-------- 159
            :.:.:....:|.:.|               |:..|..|..|          |.|.|.
  Fly   159 RCTKFFGGDSPGMLD---------------YMMWPWCERFDSLKYTFEQKFELSPERFPTLIKWR 208

Human   160 --------------EGVSQRKFLDGNELTLADCNLL 181
                          :|.:..|:::......||.|:|
  Fly   209 DLMIQDRAVKCFYLDGQTHAKYMNSRRSGQADYNML 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC1	NP_001279.2	Required for insertion into the membrane	2..90		13/69 (19%)
		O-ClC	6..241	CDD:129941	40/231 (17%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	24..27		2/2 (100%)
GstO1	NP_648237.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	3..95	CDD:469754	12/64 (19%)
		GST_C_Omega	109..234	CDD:198293	18/139 (13%)