Protein Alignment CLIC1 and GstO3

DIOPT Version :10

• Sequence 1: NP_001279.2
• Gene: CLIC1 / 1192
• HGNCID: 2062
• Length: 241
• Species: Homo sapiens
• Sequence 2: NP_648234.1
• Gene: GstO3 / 38972
• FlyBaseID: FBgn0035904
• Length: 241
• Species: Drosophila melanogaster
• Alignment Length: 190
• Identity: 40/190 - (21%)
• Similarity: 75/190 - (39%)
• Gaps: 43/190 - (22%)

Human    24 CPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVL 88
            ||::||..:||..|.|.::...::...:.|.:.::.|..::|.|....| ..:.:.||..:.|..
  Fly    30 CPYAQRAHLVLNAKNVPYHSVYINLTEKPEWLVEVSPLLKVPALQLVAE-KGEPSLIESLIIAEY 93

Human    89 CPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPAL-NDNLEKGLLKALKVLDNYLTSP-LPEE 151
            ...:||:                          ||.| .|.|::...|.|....:.:||. :...
  Fly    94 LDDKYPE--------------------------NPLLPKDPLKRAQDKILLERFSSITSAFINIL 132

Human   152 VDETSAED---------EGVSQR--KFLDGNELTLADCNLLP---KLHIVQVVCKKYRGF 197
            |..|..||         |.:::|  .:..||:....|..:.|   :|.::::..:|...|
  Fly   133 VQGTGLEDYWTALDIFEEELTKRGTPYFGGNKPGFVDYMIWPWFERLSVIELKLQKEYNF 192

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC1	NP_001279.2	Required for insertion into the membrane	2..90		16/65 (25%)
		O-ClC	6..241	CDD:129941	40/190 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	24..27		2/2 (100%)
GstO3	NP_648234.1	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold	3..95	CDD:469754	16/65 (25%)
		GST_C_Omega	109..230	CDD:198293	18/84 (21%)