DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLIC1 and GstE5

DIOPT Version :10

Sequence 1:NP_001279.2 Gene:CLIC1 / 1192 HGNCID:2062 Length:241 Species:Homo sapiens
Sequence 2:NP_611327.1 Gene:GstE5 / 37110 FlyBaseID:FBgn0063495 Length:222 Species:Drosophila melanogaster


Alignment Length:206 Identity:43/206 - (20%)
Similarity:68/206 - (33%) Gaps:58/206 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    63 QLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKF-------SAYIKN 120
            |||:......:.......||:|:.             |||.....|:....:       .||:. 
  Fly    26 QLPYEFVNVNISGQEQLSEEYLKK-------------NPEHTVPTLEDDGNYIWDSHAIIAYLV- 76

Human   121 SNPALNDNLEKGLLKALKVLDNYL---------------TSPL--------PEEVDETSAE---- 158
            |..|.:|.|....|....|:|..|               |.||        |:|..:...|    
  Fly    77 SKYADSDALYPRDLLQRAVVDQRLHFETGVVFANGIKAITKPLFFNGLNRIPKERYDAIVEIYDF 141

Human   159 -DEGVSQRKFLDGNELTLADCNLLPKL----HIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREE 218
             :..::...::.|::||:||.:|:..:    ..|::...||     |.....|.|.....|..|.
  Fly   142 VETFLAGHDYIAGDQLTIADFSLISSITSLVAFVEIDRLKY-----PRIIEWVRRLEKLPYYEEA 201

Human   219 FASTCPDDEEI 229
            .|....:.|.|
  Fly   202 NAKGARELETI 212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLIC1NP_001279.2 Required for insertion into the membrane 2..90 6/26 (23%)
O-ClC 6..241 CDD:129941 43/206 (21%)
G-site. /evidence=ECO:0000305|PubMed:25581026 24..27
GstE5NP_611327.1 GstA 4..210 CDD:440390 41/202 (20%)
Blue background indicates that the domain is not in the aligned region.

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