Protein Alignment CLIC1 and Clic

DIOPT Version :10

• Sequence 1: NP_001279.2
• Gene: CLIC1 / 1192
• HGNCID: 2062
• Length: 241
• Species: Homo sapiens
• Sequence 2: NP_572928.1
• Gene: Clic / 32349
• FlyBaseID: FBgn0030529
• Length: 260
• Species: Drosophila melanogaster
• Alignment Length: 241
• Identity: 61/241 - (25%)
• Similarity: 111/241 - (46%)
• Gaps: 28/241 - (11%)

Human     6 PQVELFVKAGS-DGAKIGNCPFSQRLFMVLW----LKGVTFNVTTVDTKRRTETVQKLCPGGQLP 65
            |::||.:||.: ||.:.|.|.|.|..||.|:    ||.::..|||||.::.....:........|
  Fly    21 PEIELIIKASTIDGRRKGACLFCQEYFMDLYLLAELKTISLKVTTVDMQKPPPDFRTNFEATHPP 85

Human    66 FLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLE 130
            .|:.......:..|||..:...: |..| .|...:.|..|...:::.|....:...:.|.|:
  Fly    86 ILIDNGLAILENEKIERHIMKNI-PGGY-NLFVQDKEVATLIENLYVKLKLMLVKKDEAKNN--- 145

Human   131 KGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYR 195
             .||..|:.::::|::                ...:||.|:.:...||.|:|:|..::|..|.:.
  Fly   146 -ALLSHLRKINDHLSA----------------RNTRFLTGDTMCCFDCELMPRLQHIRVAGKYFV 193

Human   196 GFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK 241
            .|.||.....:.||:.:.|..:.|..:||.|::| :.:.::.::||
  Fly   194 DFEIPTHLTALWRYMYHMYQLDAFTQSCPADQDI-INHYKLQQSLK 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC1	NP_001279.2	Required for insertion into the membrane	2..90		26/88 (30%)
		O-ClC	6..241	CDD:129941	59/239 (25%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	24..27		1/2 (50%)
Clic	NP_572928.1	GST_N_CLIC	18..112	CDD:239359	27/91 (30%)
		GST_C_CLIC	118..232	CDD:198307	30/134 (22%)