Protein Alignment CLIC1 and GstT2

DIOPT Version :10

• Sequence 1: NP_001279.2
• Gene: CLIC1 / 1192
• HGNCID: 2062
• Length: 241
• Species: Homo sapiens
• Sequence 2: NP_724816.3
• Gene: GstT2 / 246386
• FlyBaseID: FBgn0050005
• Length: 228
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 46/214 - (21%)
• Similarity: 69/214 - (32%)
• Gaps: 86/214 - (40%)

Human    18 GAKIGN-----CPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVH--- 74
            |.|..|     ||.:.|.|..|           .|..::....||: |.      :.|.:.|
  Fly    22 GLKFSNSPVEYCPIALRKFEQL-----------TDEYKKINRFQKV-PA------IVGGDFHLSE 68

Human    75 --------TDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKF---------SAYIKNSN 122
                    .|..:.:|.|        |||..     .|.|.:|.|.::         |.|.:::
  Fly    69 TIAIIRYLADKGQFDEKL--------YPKTL-----ENRARVDEFLEWQHLNIRLACSMYFRDA- 119

Human   123 PALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVS-----------QRKFLDGNELTLA 176
                         .|..::.....|.||::   .|..|||.           :..||.|..||:|
  Fly   120 -------------WLFPMNGIAPKPKPEQI---QALIEGVENNLGLLERLWLENDFLVGKNLTMA 168

Human   177 DCNLLPKLHIVQVVCKKYR 195
            |  :|....|.|:...:||
  Fly   169 D--ILGSSEINQLRLCQYR 185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLIC1	NP_001279.2	Required for insertion into the membrane	2..90		17/87 (20%)
		O-ClC	6..241	CDD:129941	46/214 (21%)
		G-site. /evidence=ECO:0000305|PubMed:25581026	24..27		2/2 (100%)
GstT2	NP_724816.3	GST_N_Theta	5..80	CDD:239348	15/75 (20%)
		GST_C_family	93..218	CDD:470672	26/112 (23%)