DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ate1 and Ate1

DIOPT Version :9

Sequence 1:	XP_006507327.1	Gene:	Ate1 / 11907	MGIID:	1333870	Length:	559	Species:	Mus musculus
Sequence 2:	NP_001261101.1	Gene:	Ate1 / 37288	FlyBaseID:	FBgn0025720	Length:	485	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	211/560 - (37%)
Similarity:	292/560 - (52%)	Gaps:	91/560 - (16%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 SPSLVEYFEGQTSFQCGYCKNKLGSRSYGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMDQTCC 72
            |.|:|.|:..|.| :||||.....|.|:||.|:.:..:||||||||||||.|.|.||....:|||
  Fly     2 SLSIVSYYGSQQS-KCGYCAGANCSLSHGMHAYQLDCRDYQDLIDRGWRRCGYYCYKLRNQETCC 65

Mouse    73 PQYTIRCHPLQFQPSKSHKKVLKKMLKFLAKGEISKGNCEDEPMDSTVEDAVDGDFALINKLDIK 137
            |.|||:|:.|:|:.|||:|::|:::.:||..|:     .|.:|.....:...|.|:|::
  Fly    66 PCYTIKCNGLEFKLSKSNKRILRRINRFLRDGK-----RESKPEAGDGDGEADADYAIV------ 119

Mouse   138 CDLKTLSDLKGS--------IESEEKEKEKSIKKEGSKEFIHPQSIEEKLGSGEPSHPIKVHIGP 194
            ....|.|:.:..        |..|:.....:.:::.:|:..........|||.:.|.       .
  Fly   120 APEVTASEPQPQLPDKSPPVINVEQVASLATAQRKPTKQATAAAVEAPTLGSNKSSL-------L 177

Mouse   195 KPGKGADLSKPPCRKAREMRKERQRLKRMQQASAAASEAQGQPVCLLPKAKSNQPKSLEDLIFQS 259
            .....|.:|..||:||::||.:|:..|....||.:....             .|.|:|.|.: .:
  Fly   178 SSSAAAPISNKPCKKAKQMRLDRRLAKLGDSASYSTKSL-------------TQEKTLRDFL-NT 228

Mouse   260 LPENASHKLEVRVVRSSPPSPQFRATFQESYQVYKRYQMVVHKDPPDKPTVSQVRLVPASFEDPE 324
            ..|...|:|::.:|.||...   |........:|::||:.||.|.|       .||..||.:
  Fly   229 DSETNKHRLKIVLVASSDTE---RTCADAVIALYRKYQITVHNDNP-------ARLTLASMQ--- 280

Mouse   325 FNSSFNQSFSLYTKYQVAIHQEAPEICEKSEFTRFLCSSPLEAEHPADGPECGYGSFHQQYWLDG 389
                                             |||..|||:.|.|.||||.||||||||||||.
  Fly   281 ---------------------------------RFLVKSPLKNEKPWDGPEMGYGSFHQQYWLDD 312

Mouse   390 KIIAVGVLDILPYCVSSVYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSC 454
            |:|||||:||||.||||||.:|||||||||||.|.:||||...:.|.||...|.|||||||||||
  Fly   313 KLIAVGVIDILPGCVSSVYFFYDPDYSFLSLGTYGSLREIELVQSLAEKVPSLKYYYMGFYIHSC 377

Mouse   455 PKMRYKGQYRPSDLLCPETYVWVPIEQCL-PSLDNSKYCRFNQDPEAED--EGRSKELDRLR-VF 515
            |||||||:..||.|||||||.|:|:...: ..||..||.|.|:||.|.|  |...:.||.:: :.
  Fly   378 PKMRYKGKLSPSYLLCPETYEWLPLTDVIRAKLDEHKYQRLNEDPAARDVNEFLMEHLDEVKLLL 442

Mouse   516 HRRSAMPYGVYKNHQEDPSEEAGVLEYANLVGQKCSERML 555
            ..|:...|..::..:...|::..::||:.|||::|:.|||
  Fly   443 GGRTRTDYKHFRQLRGTVSDDDIIIEYSKLVGKECARRML 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ate1	XP_006507327.1	ATE_N	23..92	CDD:377334	38/68 (56%)
Ate1	XP_006507327.1	ATE_C	331..470	CDD:377335	81/138 (59%)
Ate1	NP_001261101.1	ATE_N	14..85	CDD:282259	39/70 (56%)
Ate1	NP_001261101.1	ATE_C	256..395	CDD:282260	50/138 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850740
Domainoid	1	1.000	192	1.000	Domainoid score	I3226
eggNOG	1	0.900	-	-		E1_COG2935
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31420
Inparanoid	1	1.050	355	1.000	Inparanoid score	I2224
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55132
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004464
OrthoInspector	1	1.000	-	-		oto95025
orthoMCL	1	0.900	-	-		OOG6_103364
Panther	1	1.100	-	-	LDO	PTHR21367
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R102
SonicParanoid	1	1.000	-	-		X3164
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790