Protein Alignment PDZD8 and Pdzd8

DIOPT Version :10

• Sequence 1: NP_776152.1
• Gene: PDZD8 / 118987
• HGNCID: 26974
• Length: 1154
• Species: Homo sapiens
• Sequence 2: NP_572771.1
• Gene: Pdzd8 / 32157
• FlyBaseID: FBgn0030358
• Length: 1037
• Species: Drosophila melanogaster
• Alignment Length: 1190
• Identity: 288/1190 - (24%)
• Similarity: 479/1190 - (40%)
• Gaps: 261/1190 - (21%)

Human     3 LLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDE 67
            :||:.|...::|..:.:|.|:.:..:....|...|..:.... :|..|:........|      :
  Fly     8 ILLLCLIFLLIGGVVMILLQYLIFIKFSNLPDESEEQKQANA-KYTLPLNIKQTARNL------K 65

Human    68 EPSGAAPEGGATPTAAPETPAPPTRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQ 132
            ..|.:...|||.........:.........||..:.|||.|.:::...|:|..:|:.:|.:||:.
  Fly    66 RLSNSGLGGGAGNGCENHQESLRRASALVSLNFVMQFLFHEFKNSNRVRKWFYRKLSIELDELIS 130

Human   133 TKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGEALPAACPEELAFEAEVE 197
            ..|.|:||:.|:::::.||:..|.:|::. |..|      |.|..|...      |.|....::.
  Fly   131 KTTTGKLLDKLTIKELELGDQFPDVKSLS-VHNV------ELDKDEQRI------ENLDLLLDIN 182

Human   198 YNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGR 262
            |.|.|..:||.|:|.||...:.:::.::.|..||.|||.|:|||..||:.||.:..::.|:::||
  Fly   183 YVGNFTTSIDADMVLGKKGSITLRVKQLSGMARLQFTRKPYTHWSISFLGDPELILDIESKYQGR 247

Human   263 PM-PQLTSIIVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVT 326
            .| ..:|::|.||::|.::|||||||||:|:||||.:..    |||.....||    ..|.|.|.
  Fly   248 QMQSNITNLISNQIRKAVRRKHTLPNYKLRYKPFFHWTA----EEDASDCDIQ----PNGLLTVK 304

Human   327 LLECSRLLIFGSYDREANVHCTLELSSSVW-EEKQRSSIKT-----VELIKGNLQSVGLTLRLVQ 385
            |.|.|||:   .|...:..:||:.|:...: |..||.|...     |.:.|...|.:|:..:  |
  Fly   305 LAELSRLM---GYPGASETYCTITLAPVPFIEASQRDSRNVLISLDVFIHKAKNQQIGIVFK--Q 364

Human   386 STDGYAGHVI-IETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVL-VYYERP 448
            |    ...|: ||:|.||:||..::|..||.|:||.|..:|:..|:.|::|.....|. :..||.
  Fly   365 S----GSQVVRIESVLPNTPACKSNLLAGDVLVAIEGRPVTTIQQIAKVVKTLQATVFSLRIERI 425

Human   449 V-GQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAAGLTVDTESRELDSEFEDLASDVRAQNEFK 512
            : |.....|:|:|                 :|                 ::||:..
  Fly   426 IPGIIRNDAILED-----------------FE-----------------KYEDIGD--------- 447

Human   513 DEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEITDPAQ 577
                        :|:                     |:|..||:::.:.....|.....:..|:.
  Fly   448 ------------LPS---------------------SYPCQPKLETDEAATADPTPKHLVVKPSL 479

Human   578 VSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAI 642
            ...||........:....:..:...|.|.....:.|...:|.:        ||..:|. |:.|..
  Fly   480 SGTPTNSPKKSNLIAKAIKKTMSRESGDKDRDKDKDKDKDKDK--------DKDKDKD-KDKDKD 535

Human   643 DDAAAPKQFLAKQEVAKDVT-----SETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLF 702
            .|.       .|:||.:.|.     |...||            .|.:::...:         |.|
  Fly   536 KDK-------GKEEVEEPVNYFYQHSTIDCP------------FSPLIHMEDV---------CSF 572

Human   703 DIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLSKLRLEAPSPKAIVT 767
            .::...|:||:.::.:   ..|..:.||:.::::..:.:.|..||..:.|.::.|...|.:|:.|
  Fly   573 QLDNSSRFLNVCVFGK---SAGESVLLGYNNVQIGQILVECSETSLNQCLKQISLNPASLQAVKT 634

Human   768 RTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHV----VTNVEKEKEP---HLVEEVSVLP 825
            ..    ||.|.|||...|:|||...|.::  |..:..|    :.:..|.:.|   .|..:.....
  Fly   635 HP----LSNQSGFNPNLCFGDILFGFSWM--GNPNLTVGDVPIKSTSKSQSPARNPLAGDRVASE 693

Human   826 KEEQFV--------------GQMGLT--ENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAY 874
            .:.||:              ...|.|  ...|.|..|.|...|.||:|.||:|.|.|.||..|:.
  Fly   694 DQSQFLKLTSSMADSSTSGESSSGTTAAPRAHDFVRTHFHRATQCDFCGKKIWLKDAMQCQECSM 758

Human   875 VCHKKCQEKCLAETSVCGATD---------------RRIDRTL---KNLRLEGQETLLGLPPRVD 921
            .|||||..||...| |||..|               .|.:.|:   .|.::....|  |..|..:
  Fly   759 CCHKKCIVKCQMAT-VCGPVDCTGSIPATSSTPSMASRPEFTITQADNPQIVDSST--GATPFDE 820

Human   922 AEASKSVNK-------TTGLTRHIINTSSRLLNLRQVSKTRLSEPG-------------TDLVEP 966
            ..|:...::       .:||..|..:.:..|....:...:.|..||             :..:.|
  Fly   821 TSAASGGDQGQIQSPTASGLDVHRSSLTGMLAQGIKRQASNLDIPGIVSSLTGSGQQVNSKSLPP 885

Human   967 SPKHTPNTSDNEGSDTEVCGPNSP--SKRGNSTGIKLVRKEGGLDDSVFIA-------------- 1015
            ||:|||:...:...:.......:|  |...:...:.|...|...:..:.|.
  Fly   886 SPQHTPSRKSSIVEEATPALQQNPFESVTQHLEALPLDCPELSFEQVIVITEPIIRHTRNEDLMN 950

Human  1016 -VKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAK 1079
             .|...:.||..||.:||:.|:..:|.||:..:|.|.|....:...||.|..:..||      .:
  Fly   951 LAKSTSKLLYAALPPDERVAKINELLTKLKVALDAETEGYTLMNDAEKATESSPWKS------DR 1009

Human  1080 SGERLQALTLLMIHYRAGIE 1099
            |.||:|||:::|::...|::
  Fly  1010 SDERVQALSIIMLYLCTGLQ 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PDZD8	NP_776152.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	66..90		4/23 (17%)
		SMP_PDZD8	93..296	CDD:439230	72/203 (35%)
		PDZ	364..448	CDD:214570	27/90 (30%)
		PHA03379	<517..>635	CDD:223066	15/117 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	548..612		10/63 (16%)
		C1_PDZD8	838..893	CDD:410375	26/54 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	955..999		11/58 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1132..1154
Pdzd8	NP_572771.1	SMP_PDZD8	94..282	CDD:439230	72/200 (36%)
		PDZ_6	371..424	CDD:436067	19/52 (37%)
		C1_PDZD8	722..775	CDD:410375	25/53 (47%)
		Herpes_BLLF1	<786..897	CDD:282904	20/112 (18%)