DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLCNKB and ClC-a

DIOPT Version :10

Sequence 1:NP_000076.2 Gene:CLCNKB / 1188 HGNCID:2027 Length:687 Species:Homo sapiens
Sequence 2:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster


Alignment Length:574 Identity:246/574 - (42%)
Similarity:370/574 - (64%) Gaps:22/574 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    38 WL-KQKLFRLGEDWYFLMTLGVLMALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPV 101
            |: :..:.||||||.||..||::|||:|..||..:.....|..||||::.....::|::|...||
  Fly   159 WIWRHTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPV 223

Human   102 ALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKV 166
            .|:.||:||...|.|.|.||||||:||:|.||.|::||..|...|||:||:.||  ||.:.|||.
  Fly   224 CLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATL--GSGMPLGKE 286

Human   167 GPFVHLSVMMAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHF 231
            |||||::.::|..|.::.|:..|..||:|:.:|||.||.||||...||||..||||||||.:::|
  Fly   287 GPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351

Human   232 SVWDYWRGFFAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILG 296
            :|.:||||||||.|||.:||||||:....:|:.:|:.|:|..:.|||..|:|.|..:|.:||:.|
  Fly   352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGG 416

Human   297 SAYLFCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDSL 361
            ::|::..|.:..|:|:|:..:|.|..::.:|.....|:::||::|...|:|||..||..:.:..|
  Fly   417 ASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQL 481

Human   362 FDNHSWA---LMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPA 423
            |.|.:|:   |..:.::           :...|.....::||.|..:.:..|.:.|:|:|||:|:
  Fly   482 FSNFTWSRDDLTVEQAA-----------VVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPS 535

Human   424 GYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTHTISTALLA 488
            |.|:|:|..||..|||.||.::..||.|:..||..:||||||||:.|||||||:||||:|.|::.
  Fly   536 GMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVII 600

Human   489 FEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNIGSHRVRVEHFMNH 553
            ||:||||.|.:||::|||.|||:|...|||.||..:::|||||||.:|..:.|.:.:.||.||..
  Fly   601 FEMTGQITHVVPVMIAVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVR 665

Human   554 SITTL---AKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLVQALK 604
            .:..:   .....|:||:|:  :..:...|||:|.::.||:|.|:|.:|::.::
  Fly   666 DVKYIWHGISYQKLKEVLKL--NKTLRSLPLVDSPDNMILLGSVQRYELIKMIE 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLCNKBNP_000076.2 ClC_1_like 49..534 CDD:239655 220/487 (45%)
CBS_pair_voltage-gated_CLC_euk_bac 546..676 CDD:341367 18/62 (29%)
CBS repeat 552..627 CDD:341367 14/56 (25%)
CBS repeat 633..675 CDD:341367
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 220/487 (45%)
CBS_pair_SF 659..>718 CDD:449531 18/61 (30%)
CBS repeat 664..715 CDD:341358 14/52 (27%)
CBS_pair_SF <1032..1096 CDD:449531
CBS repeat 1053..1095 CDD:341358
Blue background indicates that the domain is not in the aligned region.

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