Protein Alignment CLCNKB and ClC-b

DIOPT Version :10

• Sequence 1: NP_000076.2
• Gene: CLCNKB / 1188
• HGNCID: 2027
• Length: 687
• Species: Homo sapiens
• Sequence 2: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Alignment Length: 721
• Identity: 172/721 - (23%)
• Similarity: 309/721 - (42%)
• Gaps: 148/721 - (20%)

Human    44 FRLGED---WYFLMTLGVLMALVSCAMDLAVESV-VRAHQWLYREIGDS----------HLLRYL 94
            |.|.:|   |...:.:|::.||::|.:|:.:|.: :|.:.:||..:.::          .|:.||
  Fly   139 FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRKYTFLYNSVKENVPLSDASDRDLLIPYL 203

Human    95 SWTVYPVALVSFSSGFSQSITPSSGGSGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGS 159
            .|.::.:..|:|.:.....|.|.:.|||||:||:.|.||.:...:.||....|.:|:..::..|
  Fly   204 YWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGG- 267

Human   160 TLFLGKVGPFVHLSVMMAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAAPF 217
             |..||.||.:|...::||.:.:.::||..:.       .:..::.:.::...|.||:..|.||.
  Fly   268 -LAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVLGGGAAGVSAAFGAPI 331

Human   218 SGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFRL-LAVFNSEQE-TITSLYKTSFRVDVP--FD 278
            .|:|||:|..:|.::....||...|:....|...: |:.::...: |.|.|:... :.|.|  ||
  Fly   332 GGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDFTFTGLFNLG-KFDTPLKFD 395

Human   279 LPEIFFFVALGGLCGILGSAYLFCQRIFFGFIRNNRFSSKLLATSK-----PVYSALATLVLASI 338
            ..|:..|:.||...|:||:|:             |..::|:....|     .:...|..:|:|.:
  Fly   396 YFELPIFMILGVTGGLLGAAW-------------NSLNTKINKFRKRFIPWKIGKVLEAVVVAMM 447

Human   339 TYPPSAGRFLASRLSMKQHLDSLFDNHSWAL---MTQNSSPPWPEEL---DPQH-----LWWEWY 392
                  |..||.       |...|.|....|   .|.|     |.:|   |.::     ||::
  Fly   448 ------GVTLAC-------LMIYFINDCRPLGNDPTNN-----PVQLFCEDNEYNAVAALWFQ-- 492

Human   393 HPRFTIFG------------TLAFFLVMKFWMLILAT-TIPMPAGYFMPIFVYGAAIGRLFGETL 444
            .|..|:..            |||.|.|: :::|..|| .:.:..|.|:|..:.|||.|||.....
  Fly   493 TPEATVRSLFHDPPGSHKILTLALFTVV-YYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAMLT 556

Human   445 SFIFPEGIVAGGITNPIMPGGYALAGAAA-FSGAVTHTISTALLAFEVTG-QIVHALPVLMAVLA 507
            .::||:       ...:.||.|||.|||| ..|.:..|||.:::..|.|| :.....|:::|:::
  Fly   557 YYVFPQ-------AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALIS 614

Human   508 ANAIAQSCQPSFYDGTVIVKKLPY-----LPRILGRNIGSHRVRVEHFMNHSITTLAKDMPLEEV 567
            |..:........||..:.|..:|.     ||:..|       ::....::..:..:........:
  Fly   615 AKWVGDYFNEGIYDTQIQVNHVPMLTWEPLPQYKG-------LKAREILSKPVICIKIRDSANYI 672

Human   568 VKVVTSTDVAKYPLVES------TESQILVGIVRRAQLV----QALKAEPPS-WAPGHQ-QCLQD 620
            .:::...|...:|:|:.      :|.:: .||:.|:||:    ::|..|... |.|... |..:|
  Fly   673 YEMLKKCDHNGFPVVDDVCGDRRSEGRV-CGIILRSQLIVILLKSLYVENKRFWLPETSIQTFRD 736

Human   621 ILAAGCPT---------------------EPVTLKLSPETSLHEAHNLFELLNL-HSLFVTSRGR 663
             |....|:                     .|..::::|..|:.....:|..|.| |.|.:....|
  Fly   737 -LYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENR 800

Human   664 AVGCVS 669
            ..|.::
  Fly   801 IAGIIT 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCNKB	NP_000076.2	ClC_1_like	49..534	CDD:239655	141/545 (26%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	27/158 (17%)
		CBS repeat	552..627	CDD:341367	16/86 (19%)
		CBS repeat	633..675	CDD:341367	9/38 (24%)
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	142/543 (26%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	27/157 (17%)
		CBS repeat	657..763	CDD:341367	17/107 (16%)
		CBS repeat	769..812	CDD:341367	9/38 (24%)