Protein Alignment PIK3AP1 and stumps

DIOPT Version :10

• Sequence 1: NP_689522.2
• Gene: PIK3AP1 / 118788
• HGNCID: 30034
• Length: 805
• Species: Homo sapiens
• Sequence 2: NP_731923.2
• Gene: stumps / 41770
• FlyBaseID: FBgn0020299
• Length: 1220
• Species: Drosophila melanogaster
• Alignment Length: 916
• Identity: 203/916 - (22%)
• Similarity: 330/916 - (36%)
• Gaps: 192/916 - (20%)

Human    11 DILIVYSPDAEEWCQYLQTLFLSSR-----QVRSQKILT--HRLGPEASFSAEDLSLFLSTRCVV 68
            ||||:.:..:|.  .||:..||.:.     :.|.:|...  |....:..||.|....:.:|...:
  Fly   250 DILIITAKHSER--AYLRATFLKNHFDKITKQRGRKPFNFLHIKIDDGPFSEEIAHKYQNTALQI 312

Human    69 VLLSAELVQHFHKPALLPLLQRAFHPPH-----------RVVRLLCGVRD-SEEFL-----DFFP 116
            |:|.         ||||.|       ||           ||.::|..:.| |||.:     ...|
  Fly   313 VILC---------PALLAL-------PHSFLMTQLSAIIRVEKVLAILLDVSEEKVKEMHKSALP 361

Human   117 DWAHWQELTCDDEPETYVAAVKKAISEDSGCDSVTDTEPEDEKVVSYSKQQNLPTVTSPG----- 176
            .:..|:.....|..:..::.: ..|:.|               ::..:..|..|...|.|
  Fly   362 SYYKWRRCVVRDNDQVQISNI-LGIATD---------------ILGRALCQRPPCQDSSGGGGGG 410

Human   177 ---------NLMVVQPDRIRCGAETTVYVIVR-CKLDDRVATEAEFSPEDSPSVRM-EAKVENEY 230
                     ....|.|.:::.|....|.::.. .:.:|.:..:.|.|.|   .:.: ..|..|.|
  Fly   411 LSRSFSSCTEGFTVLPKKVKLGQNKVVALLAEPLEKNDTLKLQVEKSGE---LIELRNFKCRNPY 472

Human   231 TISVKAPNLS---SGNVSLKIYSGDLVVCETVISYYTDMEEIGNLLSNAANPVEFMCQAFKIVPY 292
            |:....|...   |..:.::|...:..:....|...:.:.|:..||....:|:||||.|..|.|.
  Fly   473 TLQFNIPEACMEISTMIEIRIEKNNKSLGARPIKCESRLRELEQLLRIEDSPIEFMCHALGIGPV 537

Human   293 NTETLDKLLTESLKNNIPASGLHLFGINQLEEEDMMT--NQRDEELPTLLHFAAKYGLKNLTALL 355
            ..:.||:.|.:..:.|:|.: .||.......:....|  ....||.||||||||::||..|...|
  Fly   538 ERDALDQHLLQCFQRNMPPN-FHLLSGPSERQPHFFTRLESSPEEYPTLLHFAARWGLNRLCIQL 601

Human   356 LTCPGALQAYSVANKHGHYPNTIAEKHGFRDLRQFIDEYVETVDM--LKSHIKEELMHGE----- 413
            :.|||...|..|.|..|..|..:||:.|...|.|.|..:.|..::  :..:.|.....||
  Fly   602 MECPGGDTACGVRNCAGRTPAELAEQEGHHKLAQNIVSFAEFHELTTMYHYFKGVTPPGESCPKP 666

Human   414 EADAVYESMAH-------------LSTDLLMKCSLNPGCD-----------EDLYESMAAFVPAA 454
            .|:.|.|  ||             |.|...|:  ::.|.:           |.|..|...::...
  Fly   667 SANVVIE--AHPVKAGKTNKPPKELPTAEYME--MSSGSERENTPEVRTKTETLAISNLNYISVE 727

Human   455 TEDLYVEMLQASTSNPIPGDGFSRATKDSMIRKFLE-GNSMGMTNLERDQCHLGQEEDVYHTVDD 518
            |||   |.||||.:.          .|....:|..| ||..|.   |:....|...|..|:...:
  Fly   728 TED---ENLQASVAE----------KKVESEKKLPEAGNQPGP---EKTTNELRINEPPYYQSKE 776

Human   519 DEAFSVDLASR-------PPVPVPRPETTAPGAHQLPDNE---PYIFKVFAEKSQERPGNFYVSS 573
            ......:|.::       ...|:.:.:..:....||.:|:   .|:.:.......:..||:....
  Fly   777 QNQQPKELKNQSKSLDEVDAAPLYQTDKFSQECSQLLENQLGNDYVLQPSNVPVAQDDGNYLFQP 841

Human   574 ESIRKGPPVR--------PWRDRPQSSIYDPFAGMKTPGQR--QLITLQEQVKLGIVNVDEAVLH 628
            .:.....|:|        |.....:.|..|..|...|....  :|..:....|..::::.:..:.
  Fly   842 SNRPVEEPLRLNRCTNRQPGYGTLKRSASDASAASHTRSNADDELAEIMHDFKNNVLSIRDVEVL 906

Human   629 FKEWQLNQKKRSESFRFQQENLKRLRDSITRRQRE-KQKSGKQTDLEITVPIRHSQHLPAKVEFG 692
            .:.|: ::....:|||.:|:.:.:||....|.|.: |....::|..|...........|...:..
  Fly   907 VERWK-HRNDVQQSFREKQDQIDQLRREYERIQEQVKSHLKRETPFERIKKFFLRSKTPGGNDSL 970

Human   693 VYESGPRKSVIPPRTELRRGDWKTDSTS-------------STASSTSNRSSTRSLLSVS----S 740
            :.|:   ||.|......:.....:.|..             |::||:|.|.||.|..|.:    |
  Fly   971 LDET---KSSIATSCSFKSAGGVSSSAGAGRPISSLSLQSVSSSSSSSGRLSTGSNCSGASLGDS 1032

Human   741 GMEGDNEDNEVPE---VTRSRSPGPPQVDGTP--TMSLERPPRV--PPRAASQRPPTRETFHPPP 798
            |...|:||...|.   :.....|..|:...||  |...||...|  .|.::.||..|
  Fly  1033 GTHSDHEDRRFPHCRMMDNYMVPPTPRPVFTPSSTPGDERHQIVFPSPMSSCQRLNT-------- 1089

Human   799 PVPPRG 804
            |..|.|
  Fly  1090 PTSPTG 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIK3AP1	NP_689522.2	Necessary and sufficient to mediate inhibition of NF-kappa-B downstream of activated TLRs, may mediate interaction with MYD88 and TIRAP. /evidence=ECO:0000250	10..144		36/156 (23%)
		TIR_3	11..141	CDD:436583	35/153 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..165		0/19 (0%)
		DBB	180..318	CDD:464205	34/142 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	527..547		1/26 (4%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	571..590		3/26 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..679		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	697..805		34/132 (26%)
stumps	NP_731923.2	DBB	423..562	CDD:464205	34/142 (24%)