DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arpc1b and Arpc1

DIOPT Version :9

Sequence 1:	NP_075631.2	Gene:	Arpc1b / 11867	MGIID:	1343142	Length:	372	Species:	Mus musculus
Sequence 2:	NP_476596.1	Gene:	Arpc1 / 34793	FlyBaseID:	FBgn0001961	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	185/369 - (50%)
Similarity:	256/369 - (69%)	Gaps:	13/369 - (3%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 ISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWNKVHELKEHNGQVTGIDWAPESNRIVTCGTDRN 75
            |:||||||||||||:.|||||:|||.:.|:.|.....|.:|:.:|.|||||..:||||:|..|||
  Fly    14 ITCHAWNKDRTQIALSPNNHEIHIYSREGSDWKLADVLNQHDLRVMGIDWAKNTNRIVSCAADRN 78

Mouse    76 AYVWTL--KGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIK 138
            |||||.  .|: |||.||:|||||||.||:|:|.|||||||||:|:||:||||.||||||.||||
  Fly    79 AYVWTQGDDGK-WKPALVLLRINRAATCVKWSPAENKFAVGSGARLISVCYFESENDWWVSKHIK 142

Mouse   139 KPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFE----SS 199
            |||||||.|||||||||||.|||.|:|.|:|||:||::||.|.|||||::.|.|:||.|    .:
  Fly   143 KPIRSTVTSLDWHPNNVLLLAGSTDYKVRVFSAFIKDIEEPPTPTPWGNRKPLGQLMAEFRNSQT 207

Mouse   200 SSCGWVHGVCFSASGSRVAWVSHDSTVCLVDADKKMAVATLASETLPLLAVTFITENSLVAAGHD 264
            |..||::.|.||:.|::|.||.|||.|.:.||.....|....:..||.|:..:::..|:|.||:.
  Fly   208 SGGGWINSVSFSSDGNKVCWVGHDSCVSIADATNGNTVIRCRTGYLPFLSCEWVSPTSVVVAGYS 272

Mouse   265 CFPVLFTYDNAAVTLSFGGRLDVPKQSSQRGMTARERFQNLDKKASSEGGAATGAGLDSLHKNSV 329
            |.|:|::. .|...|...|:||..::....|:||...||::|:...:|.   |...:||:|:|::
  Fly   273 CVPLLYSL-TADGKLVLSGKLDKSQKKESSGITAMRIFQSMDRNMRTEN---TDTVVDSIHQNAI 333

Mouse   330 SQISVLSGGKAKCSQFCTTGMDGGMSIWDVK--SLESALKDLKI 371
            :.:.:.:|.||..::..|:|:||.:.||:|:  .:...:::|:|
  Fly   334 TSVRLYAGDKASATKVSTSGVDGQLVIWNVEQGGINGGMRNLQI 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arpc1b	NP_075631.2	WD 1	6..45		23/33 (70%)
		WD40 repeat	11..50	CDD:293791	24/38 (63%)
		WD40	45..264	CDD:392136	130/224 (58%)
		WD 2	50..89		23/40 (58%)
		WD40 repeat	56..93	CDD:293791	24/38 (63%)
		WD 3	94..135		32/40 (80%)
		WD40 repeat	99..138	CDD:293791	29/38 (76%)
		WD 4	140..179		29/38 (76%)
		WD40 repeat	146..199	CDD:293791	35/56 (63%)
		WD40 repeat	205..241	CDD:293791	14/35 (40%)
		WD 5	242..280		11/37 (30%)
		WD40 repeat	247..286	CDD:293791	11/38 (29%)
		WD 6	324..367		12/44 (27%)
		WD40 repeat	329..357	CDD:293791	7/27 (26%)
Arpc1	NP_476596.1	WD40	<3..236	CDD:295369	143/222 (64%)
		WD40	<3..181	CDD:225201	116/167 (69%)
		WD40 repeat	14..53	CDD:293791	24/38 (63%)
		WD40 repeat	59..97	CDD:293791	24/38 (63%)
		WD40 repeat	103..142	CDD:293791	29/38 (76%)
		WD40	146..>366	CDD:295369	93/223 (42%)
		WD40 repeat	150..203	CDD:293791	35/52 (67%)
		WD40 repeat	213..247	CDD:293791	14/33 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850176
Domainoid	1	1.000	178	1.000	Domainoid score	I3546
eggNOG	1	0.900	-	-		E1_KOG1523
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1631
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54320
OrthoDB	1	1.010	-	-		D317177at33208
OrthoFinder	1	1.000	-	-		FOG0001692
OrthoInspector	1	1.000	-	-		otm43170
orthoMCL	1	0.900	-	-		OOG6_101628
Panther	1	1.100	-	-	LDO	PTHR10709
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R87
SonicParanoid	1	1.000	-	-		X1085
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800