Protein Alignment Ranbp16 and RANBP17

DIOPT Version :10

• Sequence 1: NP_001188596.1
• Gene: Ranbp16 / 118436
• FlyBaseID: FBgn0053180
• Length: 1110
• Species: Drosophila melanogaster
• Sequence 2: XP_011532929.1
• Gene: RANBP17 / 64901
• HGNCID: 14428
• Length: 1092
• Species: Homo sapiens
• Alignment Length: 1098
• Identity: 591/1098 - (53%)
• Similarity: 784/1098 - (71%)
• Gaps: 31/1098 - (2%)

  Fly     3 IQQLEVLCKQLYEATDIRIRSEAEKALVTFVSSQDALPKCQLLLQRADSSYAQLLAASTLTKLIQ 67
            :.:|||||..||..||:..|.||||||:..:.|.:.|.||||||::..:||||||||:.|:||:.
Human     8 LAELEVLCTHLYIGTDLTQRIEAEKALLELIDSPECLSKCQLLLEQGTTSYAQLLAATCLSKLVS 72

  Fly    68 GLS---LQERIDIRSYALNYLATVPNLQHFVVQALVSLLAKLTKYGWFDSYKEEMVFQNLLEDVK 129
            .:|   :::|:|||:|.|||:|:.|.|..||:|||:.::||:||.|||:..|::.||:.::.|||
Human    73 RVSPLPVEQRMDIRNYILNYVASQPKLAPFVIQALIQVIAKITKLGWFEVQKDQFVFREIIADVK 137

  Fly   130 KFLQGSVEHCTIGVQILSQLVCEMNSVVEMDVQVSFSKMRKIATSFRDQQLLETFLLSCSLLVSA 194
            |||||:||||.|||.|||:|..|||.|   |.....:|.|||||||||..|.:..:|:||||...
Human   138 KFLQGTVEHCIIGVIILSELTQEMNLV---DYSRPSAKHRKIATSFRDTSLKDVLVLACSLLKEV 199

  Fly   195 RDNSKNISFMDESQQALISHVLRLTKNCLSFDFIGSSTDESADDMNNVQIPTAWRPAFLDSNTLK 259
              .:|.::..|:.||.|:..||:|..|||:|||||||.||||||:..|||||.||..||:..||.
Human   200 --FAKPLNLQDQCQQNLVMQVLKLVLNCLNFDFIGSSADESADDLCTVQIPTTWRTIFLEPETLD 262

  Fly   260 LFFDLYQILPNGLASYSISCLVQITSVRRSLFNNSERTKFLTHLVEGVKDILTTLHGLSDPDNYH 324
            |||:||..||..|:..::|||||..|.||||||:.||.|:|.:|::|||.||....|||||.|||
Human   263 LFFNLYHSLPPLLSQLALSCLVQFASTRRSLFNSPERAKYLGNLIKGVKRILENPQGLSDPGNYH 327

  Fly   325 EFCRLLARLKSNYQLGELIAVPCYPEAIQLIAKFTVESLHLWLFAPNSVHYLLTLWQRMVASVPY 389
            ||||.|||||:|||||||:.|..|||.|:|||.||:.||..|.|||||||||||||||||||||:
Human   328 EFCRFLARLKTNYQLGELVMVKEYPEVIRLIANFTITSLQHWEFAPNSVHYLLTLWQRMVASVPF 392

  Fly   390 VKSPDPHLLGTYTPEVIKAYIESRLDAVPVIIRDNLDDPLDDFCMVQQQLEQLSVIERCEYNKTC 454
            |||.:||||.||.||:.||:|.||||:|.:::||:|||||||...|.||||||..:.||||.|||
Human   393 VKSTEPHLLDTYAPEITKAFITSRLDSVAIVVRDHLDDPLDDTATVFQQLEQLCTVSRCEYEKTC 457

  Fly   455 NLLVQHFDQKAREYENLLQTPNANSIDITIHELQLTWLVYIIGSAIVGRLTVATSDEHDTMDAEL 519
            .||||.|||.|:.|:.||...:..::||||.|.:|.||||::|:.:.||||..::||||.||.||
Human   458 ALLVQLFDQNAQNYQKLLHPYSGVTVDITIQEGRLAWLVYLVGTVVGGRLTYTSTDEHDAMDGEL 522

  Fly   520 VIRVLQLMTLTDARLPQAGCEKLELAILSFLDQVRKMHSSEQAQK-ANLNKRLSEVFGLTDEQML 583
            ..||.||::|.|..||:...||:|||||.||||.||.:..:|.|: :.:..|:|||.|:||:..:
Human   523 SCRVFQLISLMDTGLPRCCNEKIELAILWFLDQFRKTYVGDQLQRTSKVYARMSEVLGITDDNHV 587

  Fly   584 LSFINRKIITNLKFWGRSESIITKTLMLLSELSVHFNSVRKLARLEEVQFMLTHHTSEHFPFLG- 647
            |.....||:||||:|||.|.:|::||..|::|||.:..::||.:::.|:|||.:||||||||||
Human   588 LETFMTKIVTNLKYWGRYEPVISRTLQFLNDLSVGYILLKKLVKIDAVKFMLKNHTSEHFPFLGI 652

  Fly   648 -TNSSLSEMRCRTMFYTSLGRLLMFDLGEDEERFYNFLEPLTNQFESLGSVMMDNNIFSNEEAKK 711
             .|.|||:.||||.|||:|.||||.||||||:.|.||:.|||..||::  :.:.||.|..|:.|:
Human   653 SDNHSLSDFRCRTTFYTALTRLLMVDLGEDEDEFENFMLPLTVAFETV--LQIFNNNFKQEDVKR 715

  Fly   712 VIIGLARDLRGLALPLNARIQYTMLFEW-LY--YADYLPILLRAMDLWAHDPAVTTPILKLFAEL 773
            ::|||||||||:|..||.:..|||||:| ||  |..|||:|..|::.|..:|..|||||||.|||
Human   716 MLIGLARDLRGIAFALNTKTSYTMLFDWMLYKRYPTYLPLLQNAVERWYGEPTCTTPILKLMAEL 780

  Fly   774 VHCRTQRLAGNVSSPMGILLFREASKLICIYGNRILH-QEVPRERLYPMRLKGIAICFLILKNSL 837
            :..|:|||..:||||.||||||||||::|.|||:||. ..:.::::|||:||||:||:..||::|
Human   781 MQNRSQRLNFDVSSPNGILLFREASKMVCTYGNQILSLGSLSKDQIYPMKLKGISICYSALKSAL 845

  Fly   838 GGNYVNCGVFKLYGDDTLDSVLNIIAKLILTIEQRDLIEYPKLSTAYYNLLNCLSQDHVSYLAAL 902
            .||||:.||||||||:..|:||....|::|::...||::|.|||.:||.||.||:|||:|::..|
Human   846 CGNYVSFGVFKLYGDNHFDNVLQAFVKMLLSVSHSDLLQYRKLSQSYYPLLECLTQDHMSFIINL 910

  Fly   903 EPAAFVYILKSLTKGLAALDSATYISCCTILDSIVSYIFKQLQMKVSTFPNKK---LRSLNQENV 964
            ||...:|:|.|:::||..||:....||||.||.||:|:||.:..:     .||   .|...|...
Human   911 EPPVLMYVLTSISEGLTTLDTVVSSSCCTSLDYIVTYLFKHIAKE-----GKKPLRCREATQAGQ 970

  Fly   965 QFLKVVEMNSELLQSMMSSLLNNVLQEDCRNQWSMSRPLLVLILLYEDYYRSLKDRIICAQPIEK 1029
            :.|..::.|.::||.|||.|:|.::.||||||||:|||||.||||.|.|:..|:..:|.:||:.|
Human   971 RLLHFMQQNPDVLQQMMSVLMNTIVFEDCRNQWSVSRPLLGLILLNEKYFSELRASLINSQPLPK 1035

  Fly  1030 QQTMAQWFDDLMVGIERNVSSKNKEKFTQNMSTFRRDVVNLPKSTAGGADYIATNPSS 1087
            |:.:||.|.:||.|:|:|:|.||:::||||:|.|||||....:|...      |.|.|
Human  1036 QEVLAQCFRNLMEGVEQNLSVKNRDRFTQNLSVFRRDVAEALRSDGN------TEPCS 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp16	NP_001188596.1	IBN_N	25..87	CDD:197981	33/64 (52%)
RANBP17	XP_011532929.1	CRM1	8..>291	CDD:227432	151/287 (53%)
		IBN_N	30..95	CDD:197981	33/64 (52%)