DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ranbp16 and xpo7

DIOPT Version :9

Sequence 1:	NP_001188596.1	Gene:	Ranbp16 / 118436	FlyBaseID:	FBgn0053180	Length:	1110	Species:	Drosophila melanogaster
Sequence 2:	XP_002932743.2	Gene:	xpo7 / 100038116	XenbaseID:	XB-GENE-491338	Length:	1103	Species:	Xenopus tropicalis

Alignment Length:	1083	Identity:	638/1083 - (58%)
Similarity:	820/1083 - (75%)	Gaps:	19/1083 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IQQLEVLCKQLYEATDIRIRSEAEKALVTFVSSQDALPKCQLLLQRADSSYAQLLAASTLTKLI- 66
            :.|||:|||||||.||...|.:||||||.|.:|.:.|.||||||:|..|||:|||||:.||||:
Frog    24 LAQLEILCKQLYETTDTSTRLQAEKALVEFTNSPECLSKCQLLLERGSSSYSQLLAATCLTKLVS 88

  Fly    67 ---QGLSLQERIDIRSYALNYLATVPNLQHFVVQALVSLLAKLTKYGWFDSYKEEMVFQNLLEDV 128
               ..|.|::|||||:|.|.||||.|.|..||.|||:.|.|::||.|||||.|:|.||:|::.||
Frog    89 RSTNPLPLEQRIDIRNYVLTYLATRPKLASFVTQALIQLYARITKLGWFDSQKDEYVFRNVIGDV 153

  Fly   129 KKFLQGSVEHCTIGVQILSQLVCEMNSVVEMDVQVSFSKMRKIATSFRDQQLLETFLLSCSLLVS 193
            .:|||.|||:|.|||.|||||..|:|   :.|.....:|.||||:||||..|.:.|.|||:||..
Frog   154 TRFLQDSVEYCVIGVSILSQLTNEIN---QADATHPLTKHRKIASSFRDSALFDIFTLSCNLLKQ 215

  Fly   194 ARDNSKNISFMDESQQALISHVLRLTKNCLSFDFIGSSTDESADDMNNVQIPTAWRPAFLDSNTL 258
            |  :.|::...|.||..|:..:|:||.|||:|||||:|||||:||:..|||||:||.|||||:||
Frog   216 A--SGKSLLLSDGSQHDLLMQLLKLTHNCLNFDFIGTSTDESSDDLCTVQIPTSWRSAFLDSSTL 278

  Fly   259 KLFFDLYQILPNGLASYSISCLVQITSVRRSLFNNSERTKFLTHLVEGVKDILTTLHGLSDPDNY 323
            :||||||..:|...:...:||||||.|||||||||:||.|||:|||:|||.||.....||||:||
Frog   279 QLFFDLYHSIPPNFSPLVLSCLVQIASVRRSLFNNAERAKFLSHLVDGVKRILENPQSLSDPNNY 343

  Fly   324 HEFCRLLARLKSNYQLGELIAVPCYPEAIQLIAKFTVESLHLWLFAPNSVHYLLTLWQRMVASVP 388
            |||||||||||||||||||:.|..|||.|:|||.|||.||..|.||||||||||:||||:.||||
Frog   344 HEFCRLLARLKSNYQLGELVKVENYPEVIRLIANFTVTSLQHWEFAPNSVHYLLSLWQRLAASVP 408

  Fly   389 YVKSPDPHLLGTYTPEVIKAYIESRLDAVPVIIRDNLDDPLDDFCMVQQQLEQLSVIERCEYNKT 453
            |||:.:||||.||||||.|||:.|||::|.:|:||.|:|||:|..:|||||:|||.|.||||:||
Frog   409 YVKATEPHLLETYTPEVTKAYVTSRLESVHIILRDGLEDPLEDAGLVQQQLDQLSTIGRCEYDKT 473

  Fly   454 CNLLVQHFDQKAREYENLLQTPNANSIDITIHELQLTWLVYIIGSAIVGRLTVATSDEHDTMDAE 518
            |.||||.|||.|:.|:.|||:.:|.|:::.:.|.:|||||||||:.|.||::.|::||.|.||.|
Frog   474 CALLVQLFDQSAQTYQELLQSGSAPSMELAVQEGRLTWLVYIIGAVIGGRVSFASTDEQDAMDGE 538

  Fly   519 LVIRVLQLMTLTDARLPQAGCEKLELAILSFLDQVRKMHSSEQAQKAN-LNKRLSEVFGLTDEQM 582
            ||.||||||.|||:||.|||.|||||::|||.:|.||::..:|.||:: |.:|||:|.||.||.|
Frog   539 LVCRVLQLMNLTDSRLAQAGNEKLELSMLSFFEQFRKIYIGDQVQKSSKLYRRLSDVLGLNDETM 603

  Fly   583 LLSFINRKIITNLKFWGRSESIITKTLMLLSELSVHFNSVRKLARLEEVQFMLTHHTSEHFPFLG 647
            :||....|||||||:|||.|.|.:|||.||::||:.::|||||.:|..|||||.:||||||.|||
Frog   604 VLSIFIGKIITNLKYWGRCEPITSKTLQLLNDLSIGYSSVRKLVKLSAVQFMLNNHTSEHFSFLG 668

  Fly   648 TN--SSLSEMRCRTMFYTSLGRLLMFDLGEDEERFYNFLEPLTNQFESLGSVMMDNNIFSNEEAK 710
            .|  |:||:|||||.|||:||||||.|||||||:|..|:.|||..||||..:...|| |:.:|||
Frog   669 INSQSNLSDMRCRTTFYTALGRLLMVDLGEDEEQFSQFMMPLTAAFESLAQMFNSNN-FNEQEAK 732

  Fly   711 KVIIGLARDLRGLALPLNARIQYTMLFEWLYYADYLPILLRAMDLWAHDPAVTTPILKLFAELVH 775
            :.::||.|||||:|...||:..:.|||:|:|.| |:|||.||::||.||||.|||||||.|||||
Frog   733 RSLVGLVRDLRGIAFAFNAKSSFMMLFDWIYPA-YMPILQRAIELWFHDPACTTPILKLMAELVH 796

  Fly   776 CRTQRLAGNVSSPMGILLFREASKLICIYGNRILH-QEVPRERLYPMRLKGIAICFLILKNSLGG 839
            .|:|||..:||||.|||||||.||:|..||||||. .|:|:|:||.::||||:|||.:||.:|.|
Frog   797 NRSQRLQFDVSSPNGILLFRETSKMITTYGNRILTLGELPKEQLYVLKLKGISICFSVLKAALSG 861

  Fly   840 NYVNCGVFKLYGDDTLDSVLNIIAKLILTIEQRDLIEYPKLSTAYYNLLNCLSQDHVSYLAALEP 904
            ||||.|||:||||:.||:.|....||:|::...||::|||||.:||:||..|:|||:|::|:|||
Frog   862 NYVNFGVFRLYGDEALDNALQTFVKLLLSVPHSDLLDYPKLSQSYYSLLEVLTQDHMSFIASLEP 926

  Fly   905 AAFVYILKSLTKGLAALDSATYISCCTILDSIVSYIFKQLQMKVSTFPNKKLRSLNQENVQFLKV 969
            ...:|||.|:::||.|||:.....||:.||.||:|:||||    |....|:.....||:.:||.:
Frog   927 HVIMYILSSISEGLTALDTMVCTGCCSCLDHIVTYLFKQL----SRSGKKRGAPPPQESERFLHI 987

  Fly   970 VEMNSELLQSMMSSLLNNVLQEDCRNQWSMSRPLLVLILLYEDYYRSLKDRIICAQPIEKQQTMA 1034
            ::.:.|::|.|:|::||.::.||||||||||||||.||||.|.|:..|:..|:.:||.||||.|.
Frog   988 MQQHPEMIQQMLSTVLNIIIFEDCRNQWSMSRPLLGLILLNEKYFSDLRSSIVSSQPPEKQQAMH 1052

  Fly  1035 QWFDDLMVGIERNVSSKNKEKFTQNMSTFRRDVVNLPKSTAGG 1077
            ..|::||.|||.|:.:||:::||||:|.|||:|.:..|:::.|
Frog  1053 LCFENLMEGIEGNLLTKNRDRFTQNLSAFRREVNDSMKNSSCG 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ranbp16	NP_001188596.1	IBN_N	25..87	CDD:281761	39/65 (60%)
xpo7	XP_002932743.2	CRM1	45..>321	CDD:227432	162/280 (58%)
xpo7	XP_002932743.2	IBN_N	46..112	CDD:197981	39/65 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1118	1.000	Domainoid score	I20
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22857
Inparanoid	1	1.050	1229	1.000	Inparanoid score	I184
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D198413at2759
OrthoFinder	1	1.000	-	-		FOG0004030
OrthoInspector	1	1.000	-	-		oto103602
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3705
SonicParanoid	1	1.000	-	-		X2778
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090