Protein Alignment CLCN5 and GEF1

DIOPT Version :10

• Sequence 1: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Sequence 2: NP_012574.1
• Gene: GEF1 / 853497
• SGDID: S000003801
• Length: 779
• Species: Saccharomyces cerevisiae
• Alignment Length: 800
• Identity: 252/800 - (31%)
• Similarity: 419/800 - (52%)
• Gaps: 114/800 - (14%)

Human    48 PLDREVGGIIIEDKSYNGGGIGSSNRIMDFLEEPIPGVGTYDDFNTIDWVREKSR--DRDRHREI 110
            |:::.:|         :|..:..:||..:     ||....:|.|.|||.:.|::|  ..|..||.
Yeast     7 PINQPIG---------DGEDVIDTNRFTN-----IPETQNFDQFVTIDKIAEENRPLSVDSDREF 57

Human   111 TNKS----KESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFN 171
            .|..    :|..|       |....::.:....::.|.:||.:.:....:.:.|.|.|...:..|
Yeast    58 LNSKYRHYREVIW-------DRAKTFITLSSTAIVIGCIAGFLQVFTETLVNWKTGHCQRNWLLN 115

Human   172 HEHCC-------WNSEHVTFEERD-KCPE---WNSWSQLIISTDEGAFAYIVNYFMYVLWALLFA 225
            ...||       .::.::..:.:: :|..   |.:|.           .::..:.:::|.::|||
Yeast   116 KSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAWK-----------GHVSPFIIFMLLSVLFA 169

Human   226 FLAVSLVKVFAPYACGSGIPEIKTILSGF-IIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLV 289
            .::..|||..||.|.||||.|||..:||| ..:.:||..|||||::.|.||:|||||:|||||.|
Yeast   170 LISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALPLAISSGLSVGKEGPSV 234

Human   290 HVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEV--SYYFPLKTL 352
            |.|.|||.:|.....:.....:.:.|.::||:.|||:||||||||||||.|||:  :..|...||
Yeast   235 HYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGAPIGGVLFGLEEIASANRFNSSTL 299

Human   353 WRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAW 417
            |:|::.||||..||:.|:||.|.|::||.|.:...|.:.|:..||.|||||||:|....:.||.:
Yeast   300 WKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRDWKVQEIPIFIALGIFGGLYGKYISKWNINF 364

Human   418 CRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLD-----SSKLCDY 477
            ...|| ..|..:||.|||.:..:||::::.||:.::..:|.:..||::|...|     |.:||
Yeast   365 IHFRK-MYLSSWPVQEVLFLATLTALISYFNEFLKLDMTESMGILFHECVKNDNTSTFSHRLC-- 426

Human   478 ENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRL 542
                      :|.:.............|....:::.::.:.::|.::|:|:|:|||||||..||.
Yeast   427 ----------QLDENTHAFEFLKIFTSLCFATVIRALLVVVSYGARVPAGIFVPSMAVGATFGRA 481

Human   543 LGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLE 607
            :.:.:|:..              .|...||||.||.:||||.|.|:|.:|:::|||||||||...
Yeast   482 VSLLVERFI--------------SGPSVITPGAYAFLGAAATLSGITNLTLTVVVIMFELTGAFM 532

Human   608 YIVPLMAAAMTSKWVADALG-REGIYDAHIRLNGYPFL-----EAKEEFAHKTLAMDVMKPRRND 666
            ||:|||.....::.:....| ..||.|..|.:||:|:|     |.:||...|..|..:|..:
Yeast   533 YIIPLMIVVAITRIILSTSGISGGIADQMIMVNGFPYLEDEQDEEEEETLEKYTAEQLMSSK--- 594

Human   667 PLLTVLTQDSMTVEDVETII----SETTYSGFPVVVSRE----SQRLVGFVLRRDLIISI----E 719
             |:|:  .:::.:.::|:::    ||.:..|||:....:    .:|.:|:||:|.|...|    .
Yeast   595 -LITI--NETIYLSELESLLYDSASEYSVHGFPITKDEDKFEKEKRCIGYVLKRHLASKIMMQSV 656

Human   720 NARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQ 784
            |:.|.|     |:::||.:.:..| .:....:..::|::.||.:|....|:.::..:|::||.:.
Yeast   657 NSTKAQ-----TTLVYFNKSNEEL-GHRENCIGFKDIMNESPISVKKAVPVTLLFRMFKELGCKT 715

Human   785 CLVTHNGRLLGIITKKDVLK 804
            .:|..:|.|.|::|.||:|:
Yeast   716 IIVEESGILKGLVTAKDILR 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		2/3 (67%)
GEF1	NP_012574.1	ClC_3_like	83..569	CDD:239656	185/523 (35%)
		CBS_pair_voltage-gated_CLC_euk_bac	586..736	CDD:341367	40/161 (25%)
		CBS repeat	592..687	CDD:341367	22/106 (21%)
		CBS repeat	693..735	CDD:341367	12/41 (29%)