Protein Alignment CLCN5 and clcn5

DIOPT Version :10

• Sequence 1: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Sequence 2: NP_001039210.1
• Gene: clcn5 / 734069
• XenbaseID: XB-GENE-5957241
• Length: 808
• Species: Xenopus tropicalis
• Alignment Length: 813
• Identity: 669/813 - (82%)
• Similarity: 743/813 - (91%)
• Gaps: 5/813 - (0%)

Human     8 MDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGGIIIEDKSYNGGGIGSSN 72
            |||:||::.|.:||.:|:||||:::|....:||:|.|||||:||::.|..:   ||||.|:...:
 Frog     1 MDNKGFRRSSLTSFHSSTSDEDMVEINEATLDFTMTDDVPPIDRDMAGGFV---SYNGNGLHGPS 62

Human    73 RIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLL 137
            ::||||:  :||||||:|||||||||||||||||||||.:|||||||||:.|:|||||||:||||
 Frog    63 KVMDFLD--VPGVGTYEDFNTIDWVREKSRDRDRHREILSKSKESTWALLRSISDAFSGWMLMLL 125

Human   138 IGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIIS 202
            |||.:||||||||||:|||||||||||...||||||.|||.|.:||||:|:.||||.|||||::.
 Frog   126 IGLTAGSLAGLIDISSHWMTDLKEGICLPWFWFNHEQCCWQSNNVTFEDRNNCPEWRSWSQLVLG 190

Human   203 TDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVI 267
            ..||||.||:||||||||||||:.|||.||:.|||||||||||||||||||||||||||||||:|
 Frog   191 RSEGAFPYILNYFMYVLWALLFSLLAVLLVRNFAPYACGSGIPEIKTILSGFIIRGYLGKWTLII 255

Human   268 KTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAP 332
            ||:||||||||||||||||||:||||||||||||.|.||||||||||||||||||||||||||||
 Frog   256 KTMTLVLAVSSGLSLGKEGPLIHVACCCGNILCHLFTKYRKNEAKRREVLSAAAAAGVSVAFGAP 320

Human   333 IGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFI 397
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||||.||:|||
 Frog   321 IGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHAPWHLLELIPFI 385

Human   398 LLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISEL 462
            |||||||||||.|||.|||||::||||:||:|||.||||||||||:|||||:|||||:||:||||
 Frog   386 LLGIFGGLWGAFFIRGNIAWCQRRKTTKLGRYPVAEVLVVTAITAVLAFPNDYTRMSSSEMISEL 450

Human   463 FNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSG 527
            |||||||||||||||.|.:|.:|||.||||.||.|||:|||||:|.||.|.||||||||||:|||
 Frog   451 FNDCGLLDSSKLCDYVNDYNNTKGGNLPDRAAGNGVYTAMWQLSLALIFKAVITIFTFGMKVPSG 515

Human   528 LFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMT 592
            |||||||||||.||||||.||||::||.:|.:|..||:||||||||||||||||||||||.||||
 Frog   516 LFIPSMAVGAIMGRLLGVAMEQLSFYHHDWLIFRGWCNQGADCITPGLYAMVGAAACLGGATRMT 580

Human   593 VSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTLAM 657
            |||||||||||||||||||||||||||||||||||||.||||||.|||||||||||||:||||||
 Frog   581 VSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGRESIYDAHIHLNGYPFLEAKEEFSHKTLAM 645

Human   658 DVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENAR 722
            |||:||||||:|||:|||||||||:|.||:||||||||:|:|||||||||||||||||||:|:||
 Frog   646 DVMRPRRNDPILTVITQDSMTVEDIEAIINETTYSGFPIVISRESQRLVGFVLRRDLIISVESAR 710

Human   723 KKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV 787
            |||:|:||||.||||||:||.||..||:||||.|:||||||:||.||||||||||||||||||||
 Frog   711 KKQEGIVSTSQIYFTEHTPPQPPTAPPSLKLRAIMDLSPFTITDQTPMEIVVDIFRKLGLRQCLV 775

Human   788 THNGRLLGIITKKDVLKHIAQMANQDPDSILFN 820
            |||||||||||||||||||||||||||||||||
 Frog   776 THNGRLLGIITKKDVLKHIAQMANQDPDSILFN 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		9/17 (53%)
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		3/3 (100%)
clcn5	NP_001039210.1	ClC_3_like	127..632	CDD:239656	431/504 (86%)
		CBS_pair_voltage-gated_CLC_euk_bac	643..793	CDD:341367	127/149 (85%)
		CBS repeat	649..744	CDD:341367	76/94 (81%)
		CBS repeat	750..792	CDD:341367	39/41 (95%)