Protein Alignment CLCN5 and clcn5a

DIOPT Version :10

• Sequence 1: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Sequence 2: XP_001920783.2
• Gene: clcn5a / 562336
• ZFINID: ZDB-GENE-091113-15
• Length: 811
• Species: Danio rerio
• Alignment Length: 815
• Identity: 649/815 - (79%)
• Similarity: 725/815 - (88%)
• Gaps: 6/815 - (0%)

Human     8 MDNRGFQQGSFSSFQNSSSDEDLMDIPATAMDFSMRDDVPPLDREVGGIIIEDKSYNGG-GIGSS 71
            |||.|:...||:|.|:.:|||||::|....:|||..||||||||:.|..:    ||..| |....
Zfish     1 MDNTGYCGESFNSLQSGTSDEDLVEIAGATLDFSSTDDVPPLDRDYGSGV----SYGAGEGPNGI 61

Human    72 NRIMDFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLML 136
            .::||.|:||:||||||:||||||||||||:||||||||..|||||||||:..:|||||||||||
Zfish    62 PKLMDLLDEPVPGVGTYEDFNTIDWVREKSKDRDRHREIAIKSKESTWALLKRISDAFSGWLLML 126

Human   137 LIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLII 201
            |:||:||:|||.||||||||||||||:|..|||||||||||||...||:||||||:|.||::||:
Zfish   127 LVGLMSGALAGGIDISAHWMTDLKEGVCLNGFWFNHEHCCWNSNETTFQERDKCPKWKSWAELIV 191

Human   202 STDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLV 266
            .|:.|.||||:||.|||.|||||:|||||||:.|||||||||||||||||||||||||||||||:
Zfish   192 GTNSGPFAYIMNYLMYVSWALLFSFLAVSLVRAFAPYACGSGIPEIKTILSGFIIRGYLGKWTLM 256

Human   267 IKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGA 331
            |||||||||||||||||||||||||||||.|||||.|.|||:||||||||||||||.||||||||
Zfish   257 IKTITLVLAVSSGLSLGKEGPLVHVACCCANILCHLFTKYRRNEAKRREVLSAAAAVGVSVAFGA 321

Human   332 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPF 396
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||.||:||
Zfish   322 PIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHSPWHLLELIPF 386

Human   397 ILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISE 461
            ||||||||:|||.|||.||.|||:||||:||.|||:|||||||:||:|||||.||||||||||||
Zfish   387 ILLGIFGGIWGAFFIRANIWWCRRRKTTRLGHYPVLEVLVVTAVTAVLAFPNSYTRMSTSELISE 451

Human   462 LFNDCGLLDSSKLCDYEN-RFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIP 525
            |||||||||||:||:|.| ....|....|||||||..||:|||||:|.||.|::||:.|||||:|
Zfish   452 LFNDCGLLDSSQLCNYSNVSVTKSSSDALPDRPAGPDVYTAMWQLSLALIFKMLITVVTFGMKLP 516

Human   526 SGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTR 590
            |||||||||||||||||||||||||||||.:|.:|..|||.|||||||||||||||.||||||||
Zfish   517 SGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWVIFRGWCSPGADCITPGLYAMVGATACLGGVTR 581

Human   591 MTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEFAHKTL 655
            |||||||||||||||||||||||||.||||||||||||||||:||||||||||||:||||:||||
Zfish   582 MTVSLVVIMFELTGGLEYIVPLMAATMTSKWVADALGREGIYEAHIRLNGYPFLESKEEFSHKTL 646

Human   656 AMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIEN 720
            |||||:|||:||.|:|:|||.|.||:||::|:||:|||||||||.|||||||||.||||:|||:|
Zfish   647 AMDVMRPRRSDPPLSVITQDGMNVEEVESLIAETSYSGFPVVVSHESQRLVGFVQRRDLVISIDN 711

Human   721 ARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQC 785
            ||::|:||||.|.|:|||::||.||.:||.||||.|:|||||||||.|.|:||||||||||||||
Zfish   712 ARQRQEGVVSASRIFFTEYTPPQPPNSPPPLKLRGIMDLSPFTVTDHTAMDIVVDIFRKLGLRQC 776

Human   786 LVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 820
            ||||||||||||||||:|||:|||||:||||||||
Zfish   777 LVTHNGRLLGIITKKDILKHMAQMANRDPDSILFN 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		8/17 (47%)
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		3/3 (100%)
clcn5a	XP_001920783.2	ClC_3_like	129..635	CDD:239656	427/505 (85%)
		CBS_pair_voltage-gated_CLC_euk_bac	646..796	CDD:341367	115/149 (77%)
		CBS repeat	652..747	CDD:341367	66/94 (70%)
		CBS repeat	753..795	CDD:341367	37/41 (90%)