DRSC/TRiP Functional Genomics Resources

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Protein Alignment CLCN5 and ClC-a

DIOPT Version :10

Sequence 1:NP_001427685.1 Gene:CLCN5 / 1184 HGNCID:2023 Length:820 Species:Homo sapiens
Sequence 2:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster


Alignment Length:687 Identity:207/687 - (30%)
Similarity:314/687 - (45%) Gaps:153/687 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    98 REKSRDRDRHREI-----TNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMT 157
            |.|..|:.|::|:     |...:.|:|...|:|:.....|:.:.|:|::...|:.::|       
  Fly   133 RRKQEDKQRNKELLGKHSTRAKRVSSWIWRHTVARLGEDWVFLALLGIIMALLSFIMD------- 190

Human   158 DLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWAL 222
               :||          ..|.|:....:.:....|                      :..|:.|..
  Fly   191 ---KGI----------SICTNARIWLYRDLTSQP----------------------FVQYIAWVS 220

Human   223 L---FAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGK 284
            |   ....:...|.:.||.:.||||||:||||.|..::.||...|||.|.|.|...:.||:.|||
  Fly   221 LPVCLILFSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGK 285

Human   285 EGPLVHVACCCGNILCHCFNKYR---KNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYY 346
            |||.||:|.....:|......::   :||::..|:|:||.|.||...|.||:||||||:|..:.|
  Fly   286 EGPFVHIASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTY 350

Human   347 FPLKTLWRSFFAALVAAFTLRSINP-FGNSRLV--LFYVEFHT--PWHLFELVPFILLGIFGGLW 406
            |.::..||.||||:..|...|.:.. |.|:..|  ||...|.|  |:...||..|.|:|:..||.
  Fly   351 FAVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLG 415

Human   407 GA----------LFIRTNIAWCRKRKTTQLGK----YPVIEVLVVTAITAILAFP---NEYT--R 452
            ||          ||:|:|     ||....|.|    ||....|:|::|    :||   .::.  .
  Fly   416 GASYVWVHRRYVLFMRSN-----KRMNKFLQKNRFLYPGFLALLVSSI----SFPLGTGQFLAGE 471

Human   453 MSTSELISELFNDCGLLDSSKLCDYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLIL--KIVI 515
            :||.|.:::||::               |..|: .:|....|.|..:   |..:.|.:.  .::.
  Fly   472 LSTHEQVTQLFSN---------------FTWSR-DDLTVEQAAVVTH---WMTSYTSVFGNLVIY 517

Human   516 TIFTFGMKI-------PSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITP 573
            |:|||.:.|       |||:|||...:||..|||:|   |.:|........:....|.    |.|
  Fly   518 TLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGRLVG---EFMAVTFPHGVRYGGRLSP----IMP 575

Human   574 GLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRL 638
            |.||:|||||..|.||. |||:.||:||:||.:.::||:|.|.:.:..|| ||.:..|||:.|.:
  Fly   576 GGYAVVGAAAFSGSVTH-TVSVAVIIFEMTGQITHVVPVMIAVLVANAVA-ALLQPSIYDSIILI 638

Human   639 NGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDV-------------ETIISETT 690
            ...|:|.            |::.  .:..:.::..:|.| |.||             |.:....|
  Fly   639 KKLPYLP------------DLLP--SSSGMYSIFVEDFM-VRDVKYIWHGISYQKLKEVLKLNKT 688

Human   691 YSGFPVVVSRESQRLVGFVLRRDLIISIEN--ARKKQ 725
            ....|:|.|.::..|:|.|.|.:||..||.  .|:|:
  Fly   689 LRSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKR 725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLCN5NP_001427685.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Selectivity filter part_1. /evidence=ECO:0000250 241..245 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 283..287 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 527..531 2/3 (67%)
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 176/565 (31%)
CBS_pair_SF 659..>718 CDD:449531 17/59 (29%)
CBS repeat 664..715 CDD:341358 14/50 (28%)
CBS_pair_SF <1032..1096 CDD:449531
CBS repeat 1053..1095 CDD:341358
Blue background indicates that the domain is not in the aligned region.

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