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Protein Alignment CLCN5 and ClC-c

DIOPT Version :10

Sequence 1:	NP_001427685.1	Gene:	CLCN5 / 1184	HGNCID:	2023	Length:	820	Species:	Homo sapiens
Sequence 2:	NP_730105.3	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster

Alignment Length:	840	Identity:	484/840 - (57%)
Similarity:	608/840 - (72%)	Gaps:	57/840 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    25 SSDEDLMDIPATAMDFSM--------------RDDVPPLDRE-----VGGIIIEDKSYNGGGIGS 70
            :.|||::||...:....:              |:.....|.|     .||        ||||...
  Fly    67 TDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGG--------NGGGNHH 123

Human    71 SNRIM-----------------------DFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITN 112
            :.|.|                       ..:::.|||:|.|:||:||||.|:.:|||.|||.|..
  Fly   124 NQRTMHQHVPTHSAFGDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVK 188

Human   113 KSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCW 177
            |.::|.|.||....||.||||.:||:|:.:|.:||::||.|.||:|||.|||...||||.|.||:
  Fly   189 KRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCY 253

Human   178 NSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGS 242
            .::...||| ..|..|.:|.::......|...|||.|..|||||||||.|:.|||::||||||||
  Fly   254 PAKQSVFEE-GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGS 317

Human   243 GIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYR 307
            |||||||||||||||||||||||:||::.|:|:||:||:||||||:||:|.|.|||..|.|.||.
  Fly   318 GIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYG 382

Human   308 KNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPF 372
            :||||:||:|||||||||||||||||||||||||||||||||||||||||.||:|||.|||:.||
  Fly   383 RNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPF 447

Human   373 GNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIEVLVV 437
            ||...|||:||::.||..|||:||:.|||.||:.|..||:.|:.|||.||.::||:|||:|||.|
  Fly   448 GNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFV 512

Human   438 TAITAILAFPNEYTRMSTSELISELFNDCGLLD-SSKLCDYENRFNTSKGGELPD-RPAGVGVYS 500
            |.:|||:.:||.:|||:.:|||..|.:.|...| ::.||||: |.|.:.|....: ...|.||||
  Fly   513 TLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYK-RMNITSGNSFIEVTEPGPGVYS 576

Human   501 AMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCS 565
            ::|.|.||.|||:.:||||||||:|:||||||:.:|||.||::|:|:||.||.:.....|...|:
  Fly   577 SIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECA 641

Human   566 QGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREG 630
            . ::.|||||||:|||||.|||||||||||||||||||||:.||||||||||.||||.|||||:|
  Fly   642 D-SNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQG 705

Human   631 IYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFP 695
            ||||||.|||||||::||||||.|||.|||:|:||: .|.|:|||||||:|||.::.||.::|:|
  Fly   706 IYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYP 769

Human   696 VVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLS 760
            ||||||:|.||||||||||.::|.||::..:|:.|:||:.||. |.|:....|..|||:.|||::
  Fly   770 VVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTS-SQPIQNLGPQPLKLKKILDMA 833

Human   761 PFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 820
            |.||||.||||.|||:||||||||.||||||||||:|||||||:|:.||.|:||:::|||
  Fly   834 PITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN 893

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.