Protein Alignment CLCN5 and ClC-b

DIOPT Version :10

• Sequence 1: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Sequence 2: NP_610798.1
• Gene: ClC-b / 36381
• FlyBaseID: FBgn0033755
• Length: 813
• Species: Drosophila melanogaster
• Alignment Length: 848
• Identity: 242/848 - (28%)
• Similarity: 382/848 - (45%)
• Gaps: 198/848 - (23%)

Human    44 DDVPPLDREVGGIIIEDKSYNGGGIGSSNRIMDFLEEPI------PGVGTYDDFNTIDW-VREKS 101
            :.|||           |...||.. ||.||.:: ..|||      ....:..::.::|: |.|.:
  Fly    74 NSVPP-----------DIPINGSA-GSPNRNIN-SSEPIFHLRSRTAAASTPNYESLDYEVCENT 125

Human   102 RDRDRHRE-ITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICT 165
            ..:|..|: :|.:         .|:......|::.:.||:::..:|..|||....::..|
  Fly   126 LFQDEQRKRLTER---------FSLRKDIIRWIIFIQIGIITALIACTIDIIIEELSIRK----- 176

Human   166 GGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYVLWALLFAFLAVS 230
                            .||       .:||..:.:..:|......::.|..::|::::......:
  Fly   177 ----------------YTF-------LYNSVKENVPLSDASDRDLLIPYLYWLLFSIVPVAFGAA 218

Human   231 LVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCC 295
            :|....|...|||||::|:.|:|..|...:...||.:|.|.::.:|..||:.|||||::|    .
  Fly   219 MVTYIEPITAGSGIPQVKSYLNGVKIPRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIH----A 279

Human   296 GNILC---------------HCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSY 345
            |.::.               ..|..:|.:..||..|| ...|||||.||||||||:||||||.:.
  Fly   280 GAVVAAGISQGKSTTFLKDFRIFKAFRDDHEKRDFVL-GGGAAGVSAAFGAPIGGMLFSLEEAAS 343

Human   346 YFPLKTLWRSFFAALVAAFTL-------RSINPFGNSRLVLFYV-EFHTP--WHLFELVPFILLG 400
            ::....:||:..|::::.|||       ..:|.|  :...||.: :|.||  :..|||..|::||
  Fly   344 FWNQNLIWRTLVASIISVFTLNIVLSAYHGLNDF--TFTGLFNLGKFDTPLKFDYFELPIFMILG 406

Human   401 IFGGLWGALF--IRTNIAWCRKRKTT-QLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISEL 462
            :.|||.||.:  :.|.|...|||... ::||  |:|.:||..:...||.           |:...
  Fly   407 VTGGLLGAAWNSLNTKINKFRKRFIPWKIGK--VLEAVVVAMMGVTLAC-----------LMIYF 458

Human   463 FNDCGLLDSSK-------LCDYENRFNTSKGGELPDRPAGVGVYSAMW----------------- 503
            .|||..|.:..       .|: :|.:|               ..:|:|
  Fly   459 INDCRPLGNDPTNNPVQLFCE-DNEYN---------------AVAALWFQTPEATVRSLFHDPPG 507

Human   504 -----QLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSW 563
                 .|||..::..|::..|||:.:..|:|||:..|||..||||.:    |.||     ||..
  Fly   508 SHKILTLALFTVVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLLAM----LTYY-----VFPQ- 562

Human   564 CSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTG-GLEYIVPLMAAAMTSKWVADALG 627
                |:.:.||.||::||||.||||.|||:||.||:.|.|| ...:..||:.|.:::|||.|..
  Fly   563 ----AEFLHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSFFFPLIIALISAKWVGDYF- 622

Human   628 REGIYDAHIRLNGYPFLEAKEEFAHKTL-AMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTY 691
            .|||||..|::|..|.|..:....:|.| |.:::    :.|::.:..:||...  :..::.:..:
  Fly   623 NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREIL----SKPVICIKIRDSANY--IYEMLKKCDH 681

Human   692 SGFPVVVS-----RESQRLVGFVLRRDLII------SIENARKKQDGVVSTSIIYFTEHSPPLPP 745
            :|||||..     |...|:.|.:||..||:      .:||   |:..:..|||..|.:..|..|.
  Fly   682 NGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN---KRFWLPETSIQTFRDLYPRFPS 743

Human   746 YTPP---------TLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLV-THNGRLLGIITKK 800
            ....         |:.|...::.||..|.....:..:..|||.||||..|| .|..|:.||||::
  Fly   744 IKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFRALGLRHLLVINHENRIAGIITRR 808

Human   801 DVL 803
            |.:
  Fly   809 DFI 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		2/3 (67%)
ClC-b	NP_610798.1	ClC_6_like	115..639	CDD:239657	180/611 (29%)
		CBS_pair_voltage-gated_CLC_euk_bac	652..813	CDD:341367	46/169 (27%)
		CBS repeat	657..763	CDD:341367	26/110 (24%)
		CBS repeat	769..812	CDD:341367	17/43 (40%)