Protein Alignment CLCN5 and SPOM_SPBC19C7.11

DIOPT Version :10

• Sequence 1: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Sequence 2: NP_596167.2
• Gene: SPOM_SPBC19C7.11 / 2540750
• PomBaseID: SPBC19C7.11
• Length: 766
• Species: Schizosaccharomyces pombe
• Alignment Length: 754
• Identity: 238/754 - (31%)
• Similarity: 387/754 - (51%)
• Gaps: 82/754 - (10%)

Human    89 DDFNTIDWVREKSRDRDRHREITNKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISA 153
            |:|.|.|.|.|...:::..    |...:|.|:.:..:.:....|.::.:||...|..|.::||..
pombe    40 DNFETDDRVNEIINEQNEE----NVIDQSRWSKLWRIWNVGYSWFILSIIGTTVGFAAYMLDIVT 100

Human   154 HWMTDLKEGICTGGFWFNHEHCCWNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYIVNYFMYV 218
            .|::|::.|.||..:::|.:.|||.||.:    ...|..|..|:          :.:.:||.:|.
pombe   101 SWLSDIRRGYCTSHWYYNEKFCCWYSETM----GSSCTAWKPWT----------YKFSLNYLIYT 151

Human   219 LWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLG 283
            .:||||...|..:|:..||.|.||||.|||.|:|||:...:|....:::|.:.|.||::||||:|
pombe   152 AFALLFVLCAAIMVRDVAPLAAGSGISEIKCIISGFLRDSFLSFRVMLVKCVGLPLAIASGLSVG 216

Human   284 KEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFP 348
            ||||.||:|...|:.:...|...|:...:.|::..|:||:||:||||:|||||||.:||:|..:.
pombe   217 KEGPSVHLATTIGHNISKIFKYAREGSIRYRDICVASAASGVAVAFGSPIGGVLFGIEEMSGGYD 281

Human   349 LKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRT 413
            .|.:..|||..|.|...|..:|||...::|||.|.:...||.|||:.|..|||||||:|. |:..
pombe   282 PKMIVYSFFCCLSAVGVLHMLNPFRTGQVVLFEVRYSGSWHFFELLFFCFLGIFGGLYGE-FVMR 345

Human   414 NIAWCRKRKTTQLGKYPVIEVLVVTAITAILAFPNEYTRMSTSELISELFNDCGLLDSSK---LC 475
            .....:|.:...|.::.|::...||.||::::|.|.:.|:..:..:..||.:|....|.:   ||
pombe   346 LFFLIQKLRKKYLSRWGVLDAAFVTVITSLVSFLNPWLRLDMTLGMELLFQECKSSSSPELINLC 410

Human   476 DYENRFNTSKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAG 540
            |...|   :|...|               |.:....:.:...|::|.|:|:|:|:|||||||..|
pombe   411 DPSLR---TKNTIL---------------LLIATFARTIFVTFSYGAKVPAGIFVPSMAVGASFG 457

Human   541 RLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGG 605
            .::|: :.::.|.....:|....|.....|||||.||::||||.|.|:..:||::|||||||||.
pombe   458 YMIGL-IAEMIYQRFPNSVLFLACHGSESCITPGTYALLGAAASLSGIMHLTVTIVVIMFELTGA 521

Human   606 LEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLEAKEEF-AHKTLAMDVMKPRRNDPLL 669
            |.:|:|.:.....:..:.:.||:.||.|..|.:||.|.||.::.. :..|:         |.|:.
pombe   522 LNFILPTVLVVALANSIGNMLGKTGIADRSIEINGLPLLEPEKSINSSNTI---------NIPIT 577

Human   670 TVLTQDSMTVEDVE-------TIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENAR----- 722
            .|:..:.:|:..:.       .::....:||:|||:...|..|:|::.:..|..|.|.|:
pombe   578 EVMASNLITIPSIGFTWRKLLGMMEGYDFSGYPVVLDSRSNYLIGYLKKSSLKSSFEAAKLEPSF 642

Human   723 --------KKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRK 779
                    .|.|.|..:....|.|..         .:.|...:|::|.:|.....:..|..:|..
pombe   643 TFDQQLCFGKVDSVGDSKSSKFGESD---------RIDLSAYMDVNPISVLHTQSIANVAVLFEV 698

Human   780 LGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSIL 818
            |......:..:|.|:|:|:|||:|  :|....|:.:.::
pombe   699 LSPSVIFIEKDGNLVGLISKKDLL--LASKYYQEDNDLV 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		2/3 (67%)
SPOM_SPBC19C7.11	NP_596167.2	ClC_3_like	86..560	CDD:239656	186/507 (37%)
		CBS_pair_voltage-gated_CLC_euk_bac	575..724	CDD:341367	35/159 (22%)
		CBS repeat	581..675	CDD:341367	19/102 (19%)
		CBS repeat	681..723	CDD:341367	12/43 (28%)