Protein Alignment CLCN5 and clh-5

DIOPT Version :10

• Sequence 1: NP_001427685.1
• Gene: CLCN5 / 1184
• HGNCID: 2023
• Length: 820
• Species: Homo sapiens
• Sequence 2: NP_495940.1
• Gene: clh-5 / 174449
• WormBaseID: WBGene00000532
• Length: 797
• Species: Caenorhabditis elegans
• Alignment Length: 788
• Identity: 396/788 - (50%)
• Similarity: 530/788 - (67%)
• Gaps: 64/788 - (8%)

Human    65 GGGIGSSNRIMDF------------LEEPIPGV------GTYDDFNTIDWVREKSRDRDRHREIT 111
            |||..||    ||            .::.:|.|      ..|.||:||||.|:.:|||.||:.|:
 Worm    34 GGGSSSS----DFNPFGAIDDVRFKTDDDLPDVMAPPFFSKYGDFHTIDWQRDLARDRLRHKMIS 94

Human   112 NKSKESTWALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCC 176
            .|..:....|:.|..||.:||:.:|.:||.:|:.||:|||.|.||:|||.|:|...||.:|||||
 Worm    95 KKKVDFPLGLLQSGWDAGAGWICVLFVGLAAGATAGIIDIGARWMSDLKTGVCADRFWLDHEHCC 159

Human   177 WNSEHVTFEERDKCPEWNSWSQLIISTDEGAFAYI-VNYFMYVLWALLFAFLAVSLVKVFAPYAC 240
            |:|.. ||.:.|.|..|..|..::...:..:|.:: :.:..|:.||:..:.|||..||:||||||
 Worm   160 WSSND-TFYKDDDCKAWTKWPWMLNYYNSSSFLFLFLEWIFYIGWAVAMSTLAVLFVKIFAPYAC 223

Human   241 GSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNK 305
            ||||||||.|||||:|||||||||.:||::.|:|:.:||||||||||:||:|||.|||..:.|.|
 Worm   224 GSGIPEIKCILSGFVIRGYLGKWTFIIKSVGLILSSASGLSLGKEGPMVHLACCIGNIFSYLFPK 288

Human   306 YRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSIN 370
            |..||||:||:|||:||||||||||||||||||||||.||||||||:|||||.||||...||.:|
 Worm   289 YGLNEAKKREILSASAAAGVSVAFGAPIGGVLFSLEEASYYFPLKTMWRSFFCALVAGIILRFVN 353

Human   371 PFGNSRLVLFYVEFHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQ-LGKYPVIEV 434
            |||:::..||:|::...|...|||||.:||:|||:.|:|||..||.|.|.||.:: ||..|:.||
 Worm   354 PFGSNQTSLFHVDYMMKWTFIELVPFAILGLFGGIIGSLFIFANIRWSRFRKNSKMLGGNPIYEV 418

Human   435 LVVTAITAILAFPNEYTRMSTSELISELFNDC-GLLDSSKLCDYENRFNTSKGGELPDRPAGVGV 498
            :::|.:||.:::.|.:||.|...:|.:||:.| ..:|...|||.....:.:.|
 Worm   419 MLITLVTAAISYFNPFTRKSAQSMIQQLFDRCEDQIDEDSLCDQNKALSIAFG------------ 471

Human   499 YSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSW 563
                 ||...||.|.||||||||:|:|.|||:||:.:||||||:||:.::|:....|.....:.:
 Worm   472 -----QLLWALIFKFVITIFTFGIKVPCGLFVPSIGMGAIAGRILGITVDQIFRAVQATPGHSDY 531

Human   564 --CSQGADCITPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADAL 626
              |..|.||:.|||||||||||.||||||||||||||||||||.||:|||.|.|.|.|||:.|.:
 Worm   532 FTCQIGKDCVMPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTGSLEFIVPTMVATMFSKWIGDGI 596

Human   627 GREGIYDAHIRLNGYPFLEAKEEFAHKTLAMDVMKPR-----------------RNDPLLTVLTQ 674
            .:.|||:|||.|||||||::|.|:.:.|:|..||:|.                 :|:  |:|:|:
 Worm   597 SKMGIYEAHIELNGYPFLDSKGEYPYSTVASQVMRPSIHRQVADEMSMSDLRELKNE--LSVITE 659

Human   675 DSMTVEDVETIISETTYSGFPVVVSRESQRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEH 739
            ..||:.|:|:::.:|.::|||||||:.|..||||:.|||:::::..|||.|..||:.||.||::.
 Worm   660 SGMTLGDLESLLRQTDFNGFPVVVSQNSMHLVGFITRRDILLALHTARKTQPYVVTNSIAYFSDG 724

Human   740 SPPLPPYTPPTLKLRNILDLSPFTVTDLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLK 804
            .|...|..|..|:||.|||::|.||||.||||.|:|:|||||||..|||.||::||||||||:|:
 Worm   725 VPDAMPGGPAPLRLRKILDMAPMTVTDQTPMETVIDMFRKLGLRHVLVTKNGKVLGIITKKDILQ 789

Human   805 HIAQMANQ 812
            .:....:|
 Worm   790 FMRNKNSQ 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLCN5	NP_001427685.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		Selectivity filter part_1. /evidence=ECO:0000250	241..245		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	283..287		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	527..531		3/3 (100%)
clh-5	NP_495940.1	ClC_3_like	122..614	CDD:239656	280/509 (55%)
		CBS_pair_voltage-gated_CLC_euk_bac	654..790	CDD:341367	74/135 (55%)
		CBS repeat	654..741	CDD:341367	39/86 (45%)
		CBS repeat	747..789	CDD:341367	30/41 (73%)