DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CLCN2 and ClC-a

DIOPT Version :9

Sequence 1:NP_004357.3 Gene:CLCN2 / 1181 HGNCID:2020 Length:898 Species:Homo sapiens
Sequence 2:NP_788639.1 Gene:ClC-a / 41428 FlyBaseID:FBgn0051116 Length:1193 Species:Drosophila melanogaster


Alignment Length:1093 Identity:453/1093 - (41%)
Similarity:607/1093 - (55%) Gaps:224/1093 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    17 YEQTLMYGRYTQDLGAFAKEEAARIRLGGPEPWKGPPSSRAAPELLEYGRSRCARCRVCSVRCHK 81
            |..||||||||:|||.|||:||.::::  .|..:.....:...|||....:|..|   .|....:
  Fly   103 YIDTLMYGRYTKDLGEFAKDEARKLKI--LEKRRKQEDKQRNKELLGKHSTRAKR---VSSWIWR 162

Human    82 FLVSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVVLIT 146
            ..|:|:||||:||.|||::|||:|::||..|:.|..|:.|:.|.|.:...:||:|||:.||.||.
  Fly   163 HTVARLGEDWVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLIL 227

Human   147 FSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCALGSGMPLGKEGPFVHI 211
            |||||..::|||::||||||||||||||.||||||.||.:|||||||..||||||||||||||||
  Fly   228 FSAGFVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHI 292

Human   212 ASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYW 276
            ||:.|.||||.::.|.|||||||||:||||||||||||.|||||:||||||||||:|:|||||||
  Fly   293 ASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYFAVRNYW 357

Human   277 RGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYL 341
            ||||||...|.:||:||||.::.:|:.|||.|.|..:||||.|||..||:||:..|.|||.:|::
  Fly   358 RGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLVCGLGGASYVWV 422

Human   342 NRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQLSQKETLVTLFDNRTW 406
            :|:.|..||..|.:|:||.:.|.|:|..:.||:|:::||.|.|||:||:||..|.:..||.|.||
  Fly   423 HRRYVLFMRSNKRMNKFLQKNRFLYPGFLALLVSSISFPLGTGQFLAGELSTHEQVTQLFSNFTW 487

Human   407 VRQGLVEELEPPSTSQAWNPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGR 471
            .|..|.  :|..:....|.....:||..|||:.|..|.:|.:|:|||||.|.|:|||.|||.|||
  Fly   488 SRDDLT--VEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSIIASTIPVPSGMFIPVFKIGAGFGR 550

Human   472 LVGESMAAWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMI 536
            ||||.||..||.|:........|:|||||||||||.:|:||||||.|||:||:||||.|::||||
  Fly   551 LVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFSGSVTHTVSVAVIIFEMTGQITHVVPVMI 615

Human   537 AVILANAVAQSLQPSLYDSIIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLR 601
            ||::|||||..||||:|||||.||||||||:|.......|.:.|||.|||||.::....:::.|:
  Fly   616 AVLVANAVAALLQPSIYDSIILIKKLPYLPDLLPSSSGMYSIFVEDFMVRDVKYIWHGISYQKLK 680

Human   602 --LALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQE-RRATQTSPLSDQ 663
              |.|::|. |.|.||:||::||||||::|.:::.::...:...:|.:..|: ::..|...|.::
  Fly   681 EVLKLNKTL-RSLPLVDSPDNMILLGSVQRYELIKMIEKHIGREKRMEVAQKWQKEAQERALEEE 744

Human   664 ----------------EGPPTPEASVCFQVNTEDSAFPAARGET-H---KPLKPALKRGPS---- 704
                            |..|.|:.....|:..::...|..|.|| |   .|.|..||:..|    
  Fly   745 KKKQEVELKMRRPSRFEVLPAPDILSLRQIANDEMLPPKKRAETMHGSLAPRKSILKKTNSFNLK 809

Human   705 -VTRNLGESP--------TGSAESAGIALRSLF------------------CGSPPPEAASEKLE 742
             ..:.:|.||        ||::|   ..:||.|                  .||..|.|::.::|
  Fly   810 TYAQPMGHSPSITPYTTITGNSE---FRIRSAFEAIFKKSTTLQDVQPDPETGSLSPAASNHEVE 871

Human   743 ------------------------------------SCEKRKL---------------------- 749
                                                |.|..|:                      
  Fly   872 VPRTPSTPGVSKKVQLPAQSNWDFVTDQIMLQVNPISTESNKMPAEKDFTDKALSNNGDSSKQSP 936

Human   750 -------------------KRV-RISLASDADLEG------------------------------ 764
                               ||. :|..|::..:.|                              
  Fly   937 SIKFKANKVADVNRSPQTAKRCSKIRFANEVGVNGSPTRTKCKIKPENVLGYSIEDVDETTNPES 1001

Human   765 -------------------EMSPEEILEWEEQQLDEPVNF--SDCKIDPAPFQLVERTSLHKTHT 808
                               :||||:..:||.:::.:|::.  ::..|||:|||||||||:.|.|:
  Fly  1002 LAESIQKPKSVRLPRERVIDMSPEDQKQWELEEMLKPIDLQKANVHIDPSPFQLVERTSILKVHS 1066

Human   809 IFSLLGVDHAYVTSIGRLIGIVTLKELRKAIEGSVTAQGV------------KVRPPLASFR--- 858
            :||::|::|||||.||||:|:|.|||||||||...:...|            .|..||.|..   
  Fly  1067 LFSMVGINHAYVTKIGRLVGVVGLKELRKAIEDINSNSFVPPTRDEDADEKPAVEKPLLSTNSSD 1131

Human   859 ----------DSATSS----SDTETTEV-HALWGPHSRHGLPREGSPSDSDDK 896
                      |||.|:    ||.|...: |...|..|....|:|...|.|.||
  Fly  1132 KAVDMTVTSMDSALSNSENCSDIEMEHIKHTDKGTVSLTMPPQESKQSPSADK 1184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CLCN2NP_004357.3 ClC_1_like 90..567 CDD:239655 292/476 (61%)
Voltage_CLC 143..546 CDD:279048 249/402 (62%)
Selectivity filter part_1. /evidence=ECO:0000250 161..165 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 203..207 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 457..461 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 643..672 7/45 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..717 14/47 (30%)
CBS_pair_EriC_assoc_euk_bac <790..838 CDD:239964 33/47 (70%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 856..898 17/59 (29%)
ClC-aNP_788639.1 ClC_1_like 171..646 CDD:239655 292/476 (61%)
Voltage_CLC 227..615 CDD:279048 239/389 (61%)
CBS_pair_EriC_assoc_euk_bac 1000..1096 CDD:239964 40/95 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 497 1.000 Domainoid score I354
eggNOG 1 0.900 - - E1_COG0038
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3213
Inparanoid 1 1.050 774 1.000 Inparanoid score I531
Isobase 1 0.950 - 0 Normalized mean entropy S3158
OMA 1 1.010 - - QHG52624
OrthoDB 1 1.010 - - D1131873at2759
OrthoFinder 1 1.000 - - FOG0002718
OrthoInspector 1 1.000 - - otm42183
orthoMCL 1 0.900 - - OOG6_103492
Panther 1 1.100 - - LDO PTHR45720
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4171
SonicParanoid 1 1.000 - - X544
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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