DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aplp2 and Appl

DIOPT Version :9

Sequence 1:	NP_001344627.1	Gene:	Aplp2 / 11804	MGIID:	88047	Length:	763	Species:	Mus musculus
Sequence 2:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster

Alignment Length:	923	Identity:	242/923 - (26%)
Similarity:	375/923 - (40%)	Gaps:	227/923 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    15 LLVLLLLGLTAPAAALAGYIEALAANAGTGFAVAEPQIAMFC--GKLNMHVNI-QTGKWEPD--- 73
            |.|:|.:|.....||...:               |||||:.|  |::.....: :.|:|..|
  Fly    14 LWVVLAIGTAQVQAASPRW---------------EPQIAVLCEAGQIYQPQYLSEEGRWVTDLSK 63

Mouse    74 PTGTKSCLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSWCRR---DKRQCK-SHIVI-PFKC 133
            .|...:||..|.::|.||::.||...|||::|::....|..|||:   :..:|| ||..| ||:|
  Fly    64 KTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPFRC 128

Mouse   134 LVGEFVSDVLLVPDNCQFFHQERMEVCEKHQRWHTLVKEACLTEGLTLYSYGMLLPCGVDQFHGT 198
            | |.|.||.||||:.|.|.|......|....||:.....||...|:.:.|:.||||||:..|.|.
  Fly   129 L-GPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQERGMQMRSFAMLLPCGISVFSGV 192

Mouse   199 EYVCCP---QTKTVDSDST----MSKEEEEEEEDE---EDEEEDYDLDKSEFPTEADLEDFTEAA 253
            |:||||   :|..:....|    |...:.....||   .||::..|.:.|:...|.||:|..:..
  Fly   193 EFVCCPKHFKTDEIHVKKTDLPVMPAAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLM 257

Mouse   254 ADEEEEDEEEGEEV------------------VEDRDYYYDP-FKGDDYNEENPTEPSSEGTISD 299
            .|:||:|....|..                  ::|.:..||. .:||:|.|:      ..|:.|:
  Fly   258 GDDEEDDMVADEAATAGGSPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEED------GAGSESE 316

Mouse   300 KEIVHD------VKAVCSQEAMTGPCRA-VMPRWYFDLSKGKCV-----------RFIYGGCGGN 346
            .|:...      .|.|..:...:.|..| |.|.......|.:.|           .|:....|.:
  Fly   317 AEVEASWDQSGGAKVVSLKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNS 381

Mouse   347 RNNFESEDYCMAVCKAMIPP-TPLPTNDVDVYFETSADDNEHARFQKAKEQLEIRHRNRMDRVKK 410
            ...            |..|| |..||:  |.||.......||..::.::::||..||.::.||.|
  Fly   382 GTG------------AGAPPSTAQPTS--DPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMK 432

Mouse   411 EWEEAELQAKNL----PKTE---RQTLIQHFQAMVKALEKEAASEKQQLVETHLARVEAMLNDRR 468
            :|.:.|.:.:::    ||..   :|.:...||..|:|||:|..:||.||...|..||.|.:|.|:
  Fly   433 DWSDLEEKYQDMRLADPKAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRK 497

Mouse   469 RIALENYLAALQSDPPRPHRILQALRRYVRAENKDRLHTIRHYQHVL-AVDP---EKAAQMKSQV 529
            |.|:..|..||...||..|.:.:.|::.:||.:|||.|.:.||:|:| :..|   |.||..:.:.
  Fly   498 REAMTCYTQALTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRT 562

Mouse   530 MTHLHVIEERRNQSLSLLYKVP----YVAQ----------------------------------- 555
            :..|..|:...|||:::|.:.|    .:||
  Fly   563 LERLIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYR 627

Mouse   556 -EIQEEIDE-----LLQEQRADM---------------------DQFTSSISENPVDVRVSSEES 593
             ||:.::.|     |.::||.:.                     |...|.::|.......||.:|
  Fly   628 VEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPTQSSTQS 692

Mouse   594 -------EEIPPFHPLHPFPSL----SENEDTQPELYHPMKKGSGMAEQDGGLIGAEEKVINSKN 647
                   |:..|...|.|..:|    :.|.:|       .|....:::.:.|......||.....
  Fly   693 QAQQQQQEKSLPGKELGPDAALVTAANPNLET-------TKSEKDLSDTEYGEATVSTKVQTVLP 750

Mouse   648 KMDENMVIDETLDVKEMIFNAERVGGLEEEP-------------ESVGPLREDFSLSS------- 692
            .:|::.|.....||      |..|...|.||             ||...||.:|:..:
  Fly   751 TVDDDAVQRAVEDV------AAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQHAHAAKEGR 809

Mouse   693 NALIGLLVIAVAIATVIVISLVMLRKR-QYGTISHGIVEVDPM----------LTPEERHLNKMQ 746
            |....|....:|:...:.:.:.:.:.| .....:.|.:|||.:          :..||:.:..||
  Fly   810 NVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQNVTTHHPIVREEKIVPNMQ 874

Mouse   747 NHGYENPTYKYLE 759
            .:|||||||||.|
  Fly   875 INGYENPTYKYFE 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aplp2	NP_001344627.1	A4_EXTRA	42..204	CDD:128326	65/172 (38%)
		Kunitz_BPTI	309..361	CDD:278443	9/63 (14%)
		APP_E2	365..547	CDD:315580	67/193 (35%)
		APP_amyloid	709..759	CDD:313694	18/60 (30%)
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	67/187 (36%)
		APP_N	33..141	CDD:280358	43/108 (40%)
		APP_Cu_bd	143..198	CDD:289676	21/54 (39%)
		APP_E2	387..580	CDD:289677	67/194 (35%)
		GBP_C	<629..682	CDD:303769	9/52 (17%)
		APP_amyloid	834..887	CDD:287486	18/52 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844133
Domainoid	1	1.000	108	1.000	Domainoid score	I6427
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3265
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG50020
OrthoDB	1	1.010	-	-		D405630at33208
OrthoFinder	1	1.000	-	-		FOG0001588
OrthoInspector	1	1.000	-	-		otm43278
orthoMCL	1	0.900	-	-		OOG6_104222
Panther	1	1.100	-	-	O	PTHR23103
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2378
SonicParanoid	1	1.000	-	-		X996
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.890