Protein Alignment ADD1 and hts

DIOPT Version :10

• Sequence 1: NP_001341690.1
• Gene: ADD1 / 118
• HGNCID: 243
• Length: 799
• Species: Homo sapiens
• Sequence 2: NP_001097377.2
• Gene: hts / 37230
• FlyBaseID: FBgn0263391
• Length: 1833
• Species: Drosophila melanogaster
• Alignment Length: 805
• Identity: 269/805 - (33%)
• Similarity: 393/805 - (48%)
• Gaps: 172/805 - (21%)

Human    10 VTSPP-----PTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCE 69
            |..||     ||...         |::|     .:....|:.||...||::|||..|:.|..|.|
  Fly     4 VEQPPQNGIDPTAGE---------DDDN-----SKARPADIEQDMREMERRKRVEAIMGSKLFRE 54

Human    70 ELESMIQEQFKKGKNPTGLLALQQIADFMTTNVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSD 134
            |||.::......|...:|:  |||::|.:         ..|...:.::..|...:.|:||:||.:
  Fly    55 ELERIVDSARDGGAGASGI--LQQLSDIV---------GVPVSRVGSVFKSSNCMVPINDIRGVE 108

Human   135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVK 199
            |:.|.||||:|||||||.:||.||:||:|.:...||.|:..:||:||:.|:||||.|:|||:|.|
  Fly   109 SMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNK 173

Human   200 INLQGDIVDRGSTNLGVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALS 264
            :::||.||::|:||.|.|::.|.|||.::|||||::|.::|......|:|::|.||||::.:|..
  Fly   174 VDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACV 238

Human   265 LGEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQV 329
            |||:..|.|.| |.||||:..:.::|||.|||::|.|||.:..||::||||:...::|.|||.|:
  Fly   239 LGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQL 302

Human   330 RTLASAGGPDNLVLLNPEKYKA---KSRSP----------------GSPVGE--------GTGSP 367
            :.|..  |.|||||:..|..||   :||.|                |:...|        ..|||
  Fly   303 KLLPV--GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSP 365

Human   368 PKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALR-EKSKKYSDVEVPASVT--GYSFASD----- 424
            |||::|..|||||||||||.||||||.||:|.:: :..|..:|||:|.:|:  ||....:
  Fly   366 PKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEELFRQ 430

Human   425 -----GDSGTCSPLRHSFQKQQREKTRWLNSGRGDEASEEGQNGSSPKSKTKVWTNITHDHVKPL 484
                 ||.           ::..:::||||               ||....||
  Fly   431 GIWKKGDI-----------RKGGDRSRWLN---------------SPNVYQKV------------ 457

Human   485 LQSLSSGVCVPSCITNCLWTKEDGHRTSTSAV----PNLFVPLNTNPKEVQEMRNKIREQNLQDI 545
             :.|.:|...|..||.  |..| |..|.::.|    |..|||..|||:|.:.::..|::....|.
  Fly   458 -EVLETGTPDPKKITK--WVAE-GSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADK 518

Human   546 KTAGPQSQVLCGVVMDRSLVQDAPLSDCTETIEGLELTEQTFSPAKSLSFRKGELVTASKAIIEK 610
            .:|||||.:|.||..|                |...|.:.|.|.|.......|   .|||.||::
  Fly   519 ISAGPQSHILEGVTWD----------------EASRLKDATVSQAGDHVVMMG---AASKGIIQR 564

Human   611 EYQPHVIV--STTGPNPFTTLTDRELEEYRREVERKQK---GSEENLDEAREQ------KEKSPP 664
            .:|.:..|  :....|||..:||.||.||:|.||||:|   |...:.|.:..:      .:|.|.
  Fly   565 GFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAVLQAGTKKYPQ 629

Human   665 DQPAVPHPPPSTPIKLEEDLVPEP-----TTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEE 724
            .:|...|    ..|:::....|.|     ...||           |...:|..:.:...:.|:..
  Fly   630 SEPETEH----QVIEIQTQQAPVPRQAEVVLSDD-----------DSKNNEYGDDMENQLYERNR 679

Human   725 EAHRPPSPTE---APTEASPEPAPD 746
            ..|.......   |.....|.|:|:
  Fly   680 NVHNNSKCRRDLFATKRRDPHPSPE 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADD1	NP_001341690.1	Aldolase_II	145..391	CDD:469663	127/272 (47%)
		PHA03307	647..>770	CDD:223039	19/114 (17%)
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	103/209 (49%)