DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Xiap and Diap2

DIOPT Version :9

Sequence 1:	XP_011249278.1	Gene:	Xiap / 11798	MGIID:	107572	Length:	548	Species:	Mus musculus
Sequence 2:	NP_477127.1	Gene:	Diap2 / 36748	FlyBaseID:	FBgn0015247	Length:	498	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	164/540 - (30%)
Similarity:	243/540 - (45%)	Gaps:	125/540 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse    81 RLKTFANFPSSSPVSASTLARAGFLYTGEGDTVQCFSCHAAIDRWQYGDSAVGRHRRISPNCRFI 145
            ||.||..:|.::||||..|...||..||.....:|..||..||||:|||....||||.||.|..:
  Fly    12 RLATFGEWPLNAPVSAEDLVANGFFATGNWLEAECHFCHVRIDRWEYGDQVAERHRRSSPICSMV 76

Mouse   146 NGFYFENGAAQSTNPGIQNGQYKSENCVGNRNPFAPDRPPETHADYLLRTGQVVDISDTIYPRNP 210
                    .|.:....:...| :|:| .||                     .|||        :|
  Fly    77 --------LAPNHCGNVPRSQ-ESDN-EGN---------------------SVVD--------SP 102

Mouse   211 AMCS------EEARLKSFQNWPDYAHLTPRELASAGLYYTGADDQVQCFCCGGKLKNWEPCDRAW 269
            ..||      |..||.:|::||: .::||:.||.||.||....|.|:|..|.|.:..||..|.|:
  Fly   103 ESCSCPDLLLEANRLVTFKDWPN-PNITPQALAKAGFYYLNRLDHVKCVWCNGVIAKWEKNDNAF 166

Mouse   270 SEHRRHFPNC---------FFVLGRNVNVRSESGVSSDRNFPNSTNSPRNPAMAEYEARIVTFGT 325
            .||:|.||.|         .|..|:|::   |.|:       ..|..|..|..|..:||:.||..
  Fly   167 EEHKRFFPQCPRVQMGPLIEFATGKNLD---ELGI-------QPTTLPLRPKYACVDARLRTFTD 221

Mouse   326 W-TSSVN-KEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLDEKGQE 388
            | .|::. ...||:||.|....||:|:||||..||..|:..::||.:||||.|.|:::|..||..
  Fly   222 WPISNIQPASALAQAGLYYQKIGDQVRCFHCNIGLRSWQKEDEPWFEHAKWSPKCQFVLLAKGPA 286

Mouse   389 YINNIHLTHSLEESLGRTAEKTPSLTKKIDDTIFQNPMVQEAIRMGFSFKDIKKTMEEKIQTSGS 453
            |::.:..|.:...|........|:|..   |.:......:||:.:|.....::..::.|:.:||.
  Fly   287 YVSEVLATTAANASSQPATAPAPTLQA---DVLMDEAPAKEALALGIDGGVVRNAIQRKLLSSGC 348

Mouse   454 SYLSLEVL-------------------------------------------IADLVSAQKDNTE- 474
            ::.:|:.|                                           :||.:.|:....|
  Fly   349 AFSTLDELLHDIFDDAGAGAALEVREPPEPSAPFIEPCQATTSKAASVPIPVADSIPAKPQAAEA 413

Mouse   475 --------DESSQTSL---QKDISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEA 528
                    ||..:.|:   ..::|.||:.|:|::.:|||:|:|..:.:||:|||||.||.|||.:
  Fly   414 VANISKITDEIQKMSVATPNGNLSLEEENRQLKDARLCKVCLDEEVGVVFLPCGHLATCNQCAPS 478

Mouse   529 VDKCPMCYTVITFKQKIFMS 548
            |..||||...|....:.|:|
  Fly   479 VANCPMCRADIKGFVRTFLS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Xiap	XP_011249278.1	BIR	80..147	CDD:237989	31/65 (48%)
		BIR	214..284	CDD:197595	31/84 (37%)
		BIR	316..382	CDD:197595	29/67 (43%)
		UBA_BIRC4_8	421..470	CDD:270578	11/91 (12%)
		RING-HC_BIRC4_8	487..548	CDD:319628	29/60 (48%)
Diap2	NP_477127.1	BIR	12..78	CDD:237989	31/73 (42%)
		BIR	112..181	CDD:197595	29/69 (42%)
		BIR	213..281	CDD:237989	29/67 (43%)
		UBA_IAPs	320..363	CDD:270506	8/42 (19%)
		zf-C3HC4_3	447..492	CDD:290631	23/44 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830697
Domainoid	1	1.000	75	1.000	Domainoid score	I9026
eggNOG	1	0.900	-	-		E1_KOG1101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46946
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0000512
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100552
Panther	1	1.100	-	-	O	PTHR10044
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R141
SonicParanoid	1	1.000	-	-		X559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750