DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Apc and Apc2

DIOPT Version :9

Sequence 1:XP_006525592.1 Gene:Apc / 11789 MGIID:88039 Length:2870 Species:Mus musculus
Sequence 2:NP_001334699.1 Gene:Apc2 / 42871 FlyBaseID:FBgn0026598 Length:1067 Species:Drosophila melanogaster


Alignment Length:1819 Identity:441/1819 - (24%)
Similarity:618/1819 - (33%) Gaps:849/1819 - (46%)


- Green bases have known domain annotations that are detailed below.


Mouse   337 DMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHS 401
            :::|..|.:|.:.::|.::|.|.|:.||:|:||.||:         |...|:..||.|||||:|:
  Fly    12 ELTRNFLELSRNPETCTALRSSDCIQLLVQILHANDE---------GLSTAKKYASQALHNIVHN 67

Mouse   402 QPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEQGM--DQDKNPMPAPVEHQICPAVCVLMKL 464
            .|::|..:||:::|.||:||..||.......::..:.:  |:|::|:         .|:.:|||.
  Fly    68 NPEEKERQREVKMLRLLDQILDYCNFLHTQLQSGGEAIADDEDRHPL---------AAMKLLMKA 123

Mouse   465 SFDEEHRHAMNELGRKATRGISSQELGQGLSGGLQAIAELLQVDCEMYG-LTNDHYSVTLRRYAG 528
            |||||||..|.||                  |.|:||..|:.:|..::| .........||.|..
  Fly   124 SFDEEHRQTMCEL------------------GALKAIPNLVHLDHAVHGPAAGREQCNALRSYGL 170

Mouse   529 MALTNLTFGD--VANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLRE 591
            ||||||||||  |.||:.||..:..|..::|||.:..::|.||:|.||||||||||.:.|....|
  Fly   171 MALTNLTFGDENVHNKSYLCGQRQFMEVVIAQLNTAPDELLQVLAGVLRNLSWRADKHMKTIFNE 235

Mouse   592 VGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLA 656
            :|:|.:|...|::.|.|:|||::|||||||||||:.|||:.||||||||||||.|:|...:.||.
  Fly   236 LGTVTSLARAAMQNKNENTLKAILSALWNLSAHCSTNKAEFCAVDGALAFLVGMLSYEGPSKTLK 300

Mouse   657 IIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQ 721
            |||:.|||||||||.||..|.:|||||..|||..|||.|||.|||:|||:||||||||||.|:||
  Fly   301 IIENAGGILRNVSSHIAVCEPYRQILRRYNCLAILLQQLKSESLTVVSNSCGTLWNLSARCPEDQ 365

Mouse   722 EALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKAL 786
            :.|.|..|:.:|:.||.||:.|||.|||:||:||:..|..:....|  ..|.|||          
  Fly   366 QYLIDHNAIPLLRALISSKNSMIAEGSASALKNLVNFRATQELMPN--GDGGSLP---------- 418

Mouse   787 EAELDAQHLSETFDNIDNLSPKASHRSKQRHKQNLYGDYAFDANRHDDSRSDNFNTGNMTVLSPY 851
                              |..:|.|......:                     |::         
  Fly   419 ------------------LDKEAGHGGTLPRR---------------------FSS--------- 435

Mouse   852 LNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLSAYHPTTENAGTSSKRGLQITTTAAQIAKV 916
                 |..||:..|||...|.                                            
  Fly   436 -----LRLSSNPTGSLKKVRP-------------------------------------------- 451

Mouse   917 MEEVSAIHTSQDDRSSASTTEFHCVADDRSAARRSSASHTHSNTYNFTKSENSNRTCSMPYAKVE 981
                          |:.|||.|                              .||.|.       
  Fly   452 --------------STVSTTGF------------------------------LNRKCE------- 465

Mouse   982 YKRSSNDSLNSVTSSDGYGKRGQMKPSVESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGE 1046
                                                                             
  Fly   466 ----------------------------------------------------------------- 465

Mouse  1047 LDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHVIEDEIKQNEQRQARSQNTSYPVYSENTDDK 1111
                       |.|.:.||                             :|.:|.|...||..   
  Fly   466 -----------SRESIYSG-----------------------------KSDSTKYSTKSEGA--- 487

Mouse  1112 HLKFQPHFGQQECVSPYRSRGTSGSETNRMGSSHAINQNVNQSLCQEDDYEDDKPTNYSERYSEE 1176
                                                          ::.:|...||         
  Fly   488 ----------------------------------------------KNPFEIVTPT--------- 497

Mouse  1177 EQHEEEEERPTNYSIKYNEEKHH--------VDQPIDYSLKYATDISSSQKPSFSFSKNSSAQST 1233
                  ||:|.:||:||.|.|.:        :|||.|:|.:|              .:..|||:.
  Fly   498 ------EEQPIDYSMKYMEHKPNSSKTFEIDLDQPTDFSARY--------------KERRSAQTA 542

Mouse  1234 KPEHLSPSSE--NTAVPPSNAKRQNQLR-------PSSAQRNGQTQKGTTCKVPSINQETIQTYC 1289
            :||..|.::|  :..:..:.:....:||       .|:|::...|:..|......||      ||
  Fly   543 QPELKSETNEIRSKELQLTKSSSATELRNSPGLVAVSAAKQKIATETETETAERPIN------YC 601

Mouse  1290 VEDTPICFSRCSSLSSLSSADDEIGCDQTTQEADSANTLQTAEVKENDVTRSAEDPATEVPAVSQ 1354
            .|.||..|||..||:||:                                   |.|...:|    
  Fly   602 EEGTPGSFSRFDSLNSLT-----------------------------------EKPEKCMP---- 627

Mouse  1355 NARAKPSRLQASGLSSESTRHNKAVEFSSGAKSPSKSG-------AQTPKSPPEHYVQETPLVFS 1412
                                          .|:|:|:.       ..||::...  ..||||:||
  Fly   628 ------------------------------PKTPTKTAVLPVHVDGNTPQNIDS--ALETPLMFS 660

Mouse  1413 RCTSVSSLDSFESRSIA----SSVQSEPCSGMVSGIISPSDLPDSPGQTMP--PSRSK------- 1464
            |.:|:.||.. :..::|    .||.|| .|.|.||:||||:|||||.|:||  |.|.:       
  Fly   661 RRSSMDSLVG-DDETVACEDNGSVISE-YSRMQSGVISPSELPDSPTQSMPQSPRRDRKVSTQNN 723

Mouse  1465 --TPPPPPQTVQAKREVPKSKVPAAEKRESGPKQTAVNAAVQRVQVLPDVDTLLHFATESTPDGF 1527
              ||...|.||..                                     |.|..|..|.||..|
  Fly   724 LDTPEQKPSTVFE-------------------------------------DKLNRFHVEHTPAAF 751

Mouse  1528 SCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPEESNENQDKEVEKPDSEKDLLDD 1592
            ||::|||.||                                                   ::||
  Fly   752 SCATSLSNLS---------------------------------------------------MMDD 765

Mouse  1593 SDDDDIEILEECIISAMPTKSSRKAKKLAQTASKLPPPVARKPSQLPVYKLLPAQNRLQAQKHVS 1657
            |:                                                    .|.::.|:...
  Fly   766 SN----------------------------------------------------ANAIRGQRGND 778

Mouse  1658 FTPGDDVPRVYCVEGTPINFSTATSLSDLTIESPPNELATGDGVRAGIQSGEFEKRDTIPTEGRS 1722
            .....|.||.||.|.|....|.|.|.|||:|.|.||:|...:.             ..:|     
  Fly   779 INGNGDAPRSYCTEDTTAVLSKAPSNSDLSILSIPNDLNANEA-------------QPVP----- 825

Mouse  1723 TDDAQRGKISSIVT--PDLDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQ------- 1778
               |.|..::.:.|  |      ||:......|..:|:|   |:.|     :.|::.:       
  Fly   826 ---APRADVTGMDTRMP------AEDAISKMRCGGNALP---SYLP-----VSDEMSKYYVEDSP 873

Mouse  1779 -ASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKPSL 1842
             ..|..||.:...|.:.|   ..||..:|..|.                        ::::.|  
  Fly   874 CTFSVISGLSHLTVGSAK---AGPVLKLPMRTA------------------------EEAQAP-- 909

Mouse  1843 QTNAKAFNEKLPNNEDRVRGSFALDSPHHYTPIEGTPYCFSRNDSLSSLDFD-DDDVDLSREKAE 1906
                     |||.....|:|    |:.....|        .::||||||..| |||.:|..:   
  Fly   910 ---------KLPPRRSAVQG----DAEPRLPP--------KKSDSLSSLSMDSDDDCNLLSQ--- 950

Mouse  1907 LRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSSKDGPDRGA 1971
                     :.|..:|||:|:                                          ||
  Fly   951 ---------AIAAGSCRPQPS------------------------------------------GA 964

Mouse  1972 ATDEKLQNFAIENTPVCFSRNSSLSSLSDIDQENNNNKESEPIKEAEPANSQGEPSKPQASGYAP 2036
            :|...|.|                :|.|.:.:||..:|     |:.|..:      ||..|    
  Fly   965 STSSSLAN----------------ASTSTLCRENGQSK-----KQVEHGD------KPNYS---- 998

Mouse  2037 KSFHVEDTPVCFSRNSSLSSLSIDSEDD------LLQECISSAMPKKKRPSRLKSESEKQSPRK 2094
                              |..|:|.:||      |.::||.|.|.|..  ..|:||.|....|:
  Fly   999 ------------------SDDSLDDDDDDARSKSLFEQCILSGMHKSN--DALESEGEPPGQRQ 1042

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ApcXP_006525592.1 Suppressor_APC 135..215 CDD:371516
ARM 348..400 CDD:214547 20/51 (39%)
APC_rep 401..474 CDD:376216 25/74 (34%)
armadillo repeat 498..534 CDD:293788 13/36 (36%)
ARM 538..579 CDD:214547 19/42 (45%)
armadillo repeat 542..579 CDD:293788 16/36 (44%)
armadillo repeat 589..621 CDD:293788 15/31 (48%)
armadillo repeat 629..670 CDD:293788 28/40 (70%)
ARM 675..715 CDD:214547 28/39 (72%)
armadillo repeat 679..713 CDD:293788 25/33 (76%)
Arm 717..755 CDD:366143 19/37 (51%)
armadillo repeat 721..757 CDD:293788 19/35 (54%)
Arm_APC_u3 758..1045 CDD:374686 25/286 (9%)
APC_u5 1062..1161 CDD:374687 7/98 (7%)
APC_r 1283..>1300 CDD:368672 7/16 (44%)
APC_u9 1309..1395 CDD:374689 6/92 (7%)
APC_r 1663..1686 CDD:368672 11/22 (50%)
APC_u13 1688..1741 CDD:374690 10/54 (19%)
SAMP 1742..1763 CDD:368673 5/20 (25%)
APC_u14 1772..1865 CDD:374691 16/100 (16%)
APC_u15 1899..1973 CDD:374692 8/73 (11%)
SAMP 2060..2079 CDD:368673 9/24 (38%)
APC_basic 2251..2596 CDD:368684
EB1_binding 2698..2870 CDD:368678
Apc2NP_001334699.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837311
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2122
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002986
OrthoInspector 1 1.000 - - mtm8887
orthoMCL 1 0.900 - - OOG6_105450
Panther 1 1.100 - - O PTHR12607
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2401
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
109.730

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