DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Apba2 and X11Lbeta

DIOPT Version :9

Sequence 1:	NP_001278095.1	Gene:	Apba2 / 11784	MGIID:	1261791	Length:	750	Species:	Mus musculus
Sequence 2:	NP_727440.3	Gene:	X11Lbeta / 31997	FlyBaseID:	FBgn0052677	Length:	2139	Species:	Drosophila melanogaster

Alignment Length:	911	Identity:	340/911 - (37%)
Similarity:	441/911 - (48%)	Gaps:	213/911 - (23%)

- Green bases have known domain annotations that are detailed below.

Mouse     8 STASSMLDHRARPGPIPH----------DQEPESEDTELPLESYVPTGL---------------- 46
            :|||:..|.....|.:.|          :.|......:..|:|:.|..|
  Fly  1274 TTASTTTDSNGGVGGVGHHLVATLVASPNNEQAKSQCQTQLQSHPPKTLSLDQSPSNHSKVFKNI 1338

Mouse    47 --ELGTL-------RPE----SPTPEEQECHNHSPDGDSSSDYVNNTSE----EEDYDEGLPEEE 94
              ||.:|       ||:    :|.|.....|....:...||..||....    ..|.|...|..:
  Fly  1339 DPELDSLYSIGVFHRPDTVQMTPPPPAPAPHRKPNNNGCSSGVVNTNGSLAGGSNDVDLLQPSSK 1403

Mouse    95 EGVTYYIRYCPEDDSYLE-----------------------GMDCNGEEYIAHGAHPVDTDECQE 136
                 :........|.|:                       |.:|:..   |:|..|....|...
  Fly  1404 -----HTPLAAAISSTLQRSSPTSTITGNGIGNGSGKTRSAGSNCSSS---ANGGMPPPIPERTN 1460

Mouse   137 AVE--DWTDSVGPHT------HSHGA-------ENSQEYPDGHLPIPEDDPTVLEV-----HDQE 181
            .|.  ..:.|.||::      |..|.       ..|..:...|....||..|.||.     |.:.
  Fly  1461 LVSAVQRSPSPGPNSPVWLSRHLDGGAGKDLLESGSDNHSKNHSADEEDVDTDLETDRLLGHQRL 1525

Mouse   182 ED-GHYCSSK--------------------------------ESYQDYYPP-ETNGNTGGASPYR 212
            :| |:|..:|                                .|..:..|| ...|.:|......
  Fly  1526 DDQGYYDENKSWDRKPRSLLSKISPKQQIPSTKTRNGYNALLSSTPELPPPIPPKGQSGLGLGLT 1590

Mouse   213 MRRGDGDLEEQEEDIDQIVAEIKMSLSMTSITSASEASPEHMPELDPGD--------------ST 263
            :..|:|.     :.:|.:...::.|||.:| :..||.|...|| :..||              :|
  Fly  1591 LGAGNGG-----KLLDLVGGMVQRSLSRSS-SEHSEKSLSKMP-ISGGDLCAGGVDVVASTVAAT 1648

Mouse   264 EACPPSDT------GHGPGRQEARPKSLNLPPEVK---------HPGDLQ--------------- 298
            .|...:.|      |:|.|.:.:..:..|....||         :.|.:.
  Fly  1649 SATVVASTPALGSPGNGGGSERSAAEMANPGGAVKLSEQEIGTINGGSVMPLGSGSGTGSGAGSG 1713

Mouse   299 RGLKTKTRTPEERPKWPQEQVCNGLEQPRKQQRSDLNGPTDNNNIPETK-KVASFPSFVAVPGPC 362
            .|..|.|.............|..|   ......|..:|...|:|..|.| |.:......||
  Fly  1714 AGSGTGTNAAVVANSNANNNVGGG---GGGGNNSSGSGAGSNSNSGEKKVKKSKSKEGGAV---- 1771

Mouse   363 EAEDLIDGIIFAANYLGSTQLLSERNPSKNIRMMQAQEAVSRVKRMQKAAKIKKKANSEGDAQTL 427
                ||:|::|.|.|||||||:.|..|:|:.|||||:|||||:|.:.          .:||.|..
  Fly  1772 ----LIEGVLFRAKYLGSTQLVCEGQPTKSTRMMQAEEAVSRIKALA----------PDGDVQPS 1822

Mouse   428 TEVDLFISTQRIKVLNADTQETMMDHALRTISYIADIGNIVVLMARRRMPRSASQDCIETTPGAQ 492
            |||||||||::|.|||.|.:|.||||||||||||||||::||||||||.   ..|| |:..|
  Fly  1823 TEVDLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRF---VPQD-IDDAP--- 1880

Mouse   493 EGKKQYKMICHVFESEDAQLIAQSIGQAFSVAYQEFLRANGINPED---LSQKEYSDIINTQEMY 554
            :..:..|||||||||::||.|||||||||.|||.|||:||||  ||   :.:.:|.:::|:||::
  Fly  1881 KPNRTPKMICHVFESDEAQFIAQSIGQAFQVAYMEFLKANGI--EDHRFVKEMDYQEVLNSQEIF 1943

Mouse   555 NDDLIHFSNSENCKELQLEKHKGEILGVVVVESGWGSILPTVILANMMNGGPAARSGKLSIGDQI 619
            .|:|..|:..|..||:.:.|.||||||||:|||||||:||||::||:|:.|.|||.|:|:||||:
  Fly  1944 GDELEIFAKKELQKEVVVPKAKGEILGVVIVESGWGSMLPTVVIANLMSSGAAARCGQLNIGDQL 2008

Mouse   620 MSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCPPVTTVLIKRPDLKYQLGFSVQNGIICSL 684
            ::|||.|||||||:|||..||..||||.||..:|.|.||..|.||||:.|||||||||||:||||
  Fly  2009 IAINGLSLVGLPLSTCQTYIKNTKNQTVVKFTVVPCAPVVEVKIKRPETKYQLGFSVQNGVICSL 2073

Mouse   685 MRGGIAERGGVRVGHRIIEINGQSVVATAHEKIVQALSNSVGEIHMKTMPAAMFRLLTGQETPLY 749
            :||||||||||||||||||||.|||||..|||||..|:.|||||.|||||.:|||||||||.|:|
  Fly  2074 LRGGIAERGGVRVGHRIIEINNQSVVAVPHEKIVNLLATSVGEILMKTMPTSMFRLLTGQENPIY 2138

Mouse   750 I 750
            |
  Fly  2139 I 2139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Apba2	NP_001278095.1	PTB_X11	365..536	CDD:269919	102/170 (60%)
		PDZ	569..652	CDD:395476	55/82 (67%)
		PDZ	662..733	CDD:395476	57/70 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94		26/128 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..346		55/298 (18%)
		STXBP1-binding	185..271		23/132 (17%)
X11Lbeta	NP_727440.3	PTB_X11	1770..1924	CDD:269919	104/180 (58%)
		PDZ_signaling	1957..2042	CDD:238492	56/84 (67%)
		PDZ_signaling	2047..2120	CDD:238492	57/72 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845951
Domainoid	1	1.000	172	1.000	Domainoid score	I3706
eggNOG	1	0.900	-	-		E1_KOG3605
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002645
OrthoInspector	1	1.000	-	-		mtm8726
orthoMCL	1	0.900	-	-		OOG6_104247
Panther	1	1.100	-	-	O	PTHR12345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2607
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730