DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ap3b1 and AP-1-2beta

DIOPT Version :9

Sequence 1:	XP_006517586.1	Gene:	Ap3b1 / 11774	MGIID:	1333879	Length:	1118	Species:	Mus musculus
Sequence 2:	NP_523415.1	Gene:	AP-1-2beta / 32987	FlyBaseID:	FBgn0010380	Length:	921	Species:	Drosophila melanogaster

Alignment Length:	1140	Identity:	274/1140 - (24%)
Similarity:	455/1140 - (39%)	Gaps:	298/1140 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    42 KKNE--DLKQMLESNKDSAKLDAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVR 104
            ||.|  :||..|.::|...|.:|:|:::..:..||:.|.|||.||..:.:.|:|:|||||:||:.
  Fly    11 KKGEIFELKSELNNDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMN 75

Mouse   105 YAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVPIIVPVMMLAIKEASADLSPYVRKN 169
            ||:.|.|:|:::::||.:..:|.|.||||.|:|.:..|||..|...:...:::...|..|||||.
  Fly    76 YAKSQPDMAIMAVNTFVKDCEDSNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKT 140

Mouse   170 AAHAIQKLYSLDPE--QKEMLIEVIEKLLKDKSTLVAGSVVMAFEEV---CPDRIDLIHRN---Y 226
            ||..:.|||.:...  :.:..::.::.||.|.:.:|..:.|.|..|:   ......|:..|   .
  Fly   141 AAVCVAKLYDISATMVEDQGFLDQLKDLLSDSNPMVVANAVAALSEINEASQSGQPLVEMNSVTI 205

Mouse   227 RKLCNLLVDVEEWGQVVIIHMLTRYARTQFVSPWREDGGLEDNEKNFYESEEEEEEKEKSSRKKS 291
            .||...|.:..|||||.|:..|..|      ||                    ::|:|..|
  Fly   206 NKLLTALNECTEWGQVFILDSLANY------SP--------------------KDEREAQS---- 240

Mouse   292 YAMDPDHRLLIRNTKPLLQSRNAAVVMAVAQLYWHI-----SPKSEAGVISKS----LVRLLRSN 347
                     :.....|.|...|||||::..::...:     |.......::|.    ||.||.|.
  Fly   241 ---------ICERITPRLAHANAAVVLSAVKVLMKLLEMLSSDSDFCATLTKKLAPPLVTLLSSE 296

Mouse   348 REVQYIVLQNIATMSIERKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQT 412
            .||||:.|:||..:..:|..:.:..:|.|:|:..||..:|..||:|:..|||::||:.:|.|.:.
  Fly   297 PEVQYVALRNINLIVQKRPDILKHEMKVFFVKYNDPIYVKLEKLDIMIRLANQSNIAQVLSELKE 361

Mouse   413 YVRSQDKQFAAATIQTIGRCATSISEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQH 477
            |....|..|....::.|||||..:....:.|::.|:.|:..:...||.|::||||.:.:..|.::
  Fly   362 YATEVDVDFVRKAVRAIGRCAIKVEPSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKY 426

Mouse   478 GEIIRHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSEDDLVKLQILNLAA 542
            ..||..:.:.||::..|.||||::|:|||..||:.. |.::|....:.|..|:..|:||:|....
  Fly   427 ESIISTLCENLDTLDEPEARASMVWIIGEYAERIDN-ADELLDSFLEGFQDENAQVQLQLLTAVV 490

Mouse   543 KLYLTNSKQTKLLTQYILNLGKYD-QNYDIRDRTRFIRQLIVPNEKSGALSKYAKKIFLAPKP-- 604
            ||:|.....|:.|.|::|:|...| .|.|:||| .||...::..:.:.     ||::.||.||
  Fly   491 KLFLKRPSDTQELVQHVLSLATQDSDNPDLRDR-GFIYWRLLSTDPAA-----AKEVVLADKPLI 549

Mouse   605 ---APLLESPFKDRDRFQLGTLSHTLNIKASGYLELSNWPEVAPDPSVRNVEVIESAKEWTPLGK 666
               ..|||....|.      .:.|..:: ||.|
  Fly   550 SEETDLLEPTLLDE------LICHISSL-ASVY-------------------------------- 575

Mouse   667 TKKEKPMKKFYSESEEEEDEDEDEDEEEEEKEDEDENPSDSSSDSESGSGSESGDTGTEDSSEDS 731
               .||...|.                                   .|.|:     |...|..:.
  Fly   576 ---HKPPTAFV-----------------------------------EGRGA-----GVRKSLPNR 597

Mouse   732 SSGQDSETGSQAEAERQKVAKRNSKTKRKSDSENREKKNENSKASESS--SEESSSMEDSSSESE 794
            ::      ||.|.||:.                      ||:..||:.  ..:.|.:.|..|...
  Fly   598 AA------GSAAGAEQA----------------------ENAAGSEAMVIPNQESLIGDLLSMDI 634

Mouse   795 SESGSDSEPAPRNVAPAKERKPQQERHPPSKDVFLL--DLDDFNPVSTPVALPTPALSPSLIADL 857
            :.....|.||                  .:.:|.||  .||..  :..|.|...|..:.||:.|:
  Fly   635 NAPAMPSAPA------------------ATSNVDLLGGGLDIL--LGGPPAEAAPGGATSLLGDI 679

Mouse   858 EGLNLSTSSSVINVSTPVFVPTKTHELLHRMHGKGLAAHYCFPRQPCIFSDKMVSVQITLTNTSD 922
            .||..:|.|..:.:....::|.:        .||||.....|.|:     :..|.:.:||||.:.
  Fly   680 FGLGGATLSVGVQIPKVTWLPAE--------KGKGLEIQGTFSRR-----NGEVFMDMTLTNKAM 731

Mouse   923 RKIENIHI---------------------GGKGLPVGMQMHAFHPIDSLEPKGSVTVSVGIDFCD 966
            :.:.|..|                     ..:.:.|.|.:....||..:||..::.|:|..:.
  Fly   732 QPMTNFAIQLNKNSFGLVPASPMQAAPLPPNQSIEVSMALGTNGPIQRMEPLNNLQVAVKNNI-- 794

Mouse   967 STQTASFQLCTKDDCFNVTLQPPVGELLSPVAMSEKDFKKEQACLCFTSVCSANQGTL---TGMN 1028
                         |.|..                        |||...:|..|..|.|   ..:|
  Fly   795 -------------DIFYF------------------------ACLVHGNVLFAEDGQLDKRVFLN 822

Mouse  1029 ETSATLIAAPQNFTPSMILQKVVNVANLGAVPSSQDNVHRFAARTVHSGSLM------------L 1081
            .......|....:|.|.::.....:|:    ..:.:|:...|.|.|....::            |
  Fly   823 TWKEIPAANELQYTLSGVIGTTDGIAS----KMTTNNIFTIAKRNVEGQDMLYQSLKLTNNIWVL 883

Mouse  1082 VTVELKEGS-TAQLIINTEKTVIGSVLLRELKPVL 1115
            :.::|:.|: .|.|.:.:....:.:::....:.::
  Fly   884 LELKLQPGNPEATLSLKSRSVEVANIIFAAYEAII 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ap3b1	XP_006517586.1	Adaptin_N	46..582	CDD:366724	175/553 (32%)
		HEAT repeat	116..144	CDD:293787	11/27 (41%)
		HEAT repeat	150..180	CDD:293787	11/29 (38%)
		HEAT repeat	188..213	CDD:293787	6/24 (25%)
		SEEEED	<734..812	CDD:373302	15/79 (19%)
		AP3B1_C	824..969	CDD:373301	37/167 (22%)
AP-1-2beta	NP_523415.1	Adaptin_N	38..535	CDD:279882	168/537 (31%)
		HEAT repeat	51..75	CDD:293787	13/23 (57%)
		HEAT repeat	87..114	CDD:293787	10/26 (38%)
		Cnd1	99..269	CDD:289487	54/208 (26%)
		HEAT repeat	121..151	CDD:293787	11/29 (38%)
		HEAT repeat	160..186	CDD:293787	6/25 (24%)
		HEAT repeat	197..229	CDD:293787	12/31 (39%)
		HEAT repeat	393..417	CDD:293787	8/23 (35%)
		HEAT repeat	429..458	CDD:293787	13/28 (46%)
		HEAT repeat	465..495	CDD:293787	9/29 (31%)
		HEAT repeat	506..542	CDD:293787	12/41 (29%)
		Alpha_adaptinC2	703..799	CDD:197886	23/115 (20%)
		B2-adapt-app_C	809..919	CDD:198088	17/114 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5096
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323029at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820